Name: Chemical Industry Top Quality Best Price 1,1'-Carbonyldiimidazole CAS 530-62-1 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of 1,1'-Carbonyldiimidazole CAS 530-62-1

Items	Specification	Result
Appearance	Off-white crystalline powder	Off-white crystalline powder
Assay	≥98.0%	98.57%
Melting point	116.0-122.0℃	117.9-118.4℃

Parameters of 1,1'-Carbonyldiimidazole CAS 530-62-1

Product parameters
Cas number:	530-62-1
Appearance:	Off-white crystalline powder
Purity:	98%min
MOQ:	20kg
Price:	Negotiable
Package details:	20kg/drum
Brand:	Fortunachem

1,1'-Carbonyldiimidazole, commonly known as CDI (or sometimes CDIm), is a chemical reagent with the formula C₇H₆N₄O . It is widely used in organic synthesis, particularly in peptide chemistry and polymer science.

It appears as a white to off-white crystalline solid. Its primary function is to act as a coupling agent or dehydrating agent, facilitating the formation of bonds (like amide, ester, or urethane bonds) by activating carboxylic acids without producing toxic byproducts.

Here are the key selling points and advantages of CDI compared to other coupling reagents:

1. Mild and Non-Toxic Byproducts

The Advantage: When CDI reacts with a carboxylic acid, it releases imidazole and carbon dioxide ( CO₂ ) as byproducts.

Why it matters: Unlike many other coupling agents (such as DCC, which produces difficult-to-remove dicyclohexylurea precipitate, or carbodiimides that require toxic additives like HOBt), the byproducts of CDI are generally water-soluble, non-toxic, and easy to remove during workup. Imidazole can often be washed away with mild acid or water.

2. High Reactivity and Efficiency

The Advantage: CDI is highly reactive toward nucleophiles. It efficiently activates carboxylic acids to form an acyl imidazole intermediate, which then readily reacts with amines (to form amides) or alcohols (to form esters).

Why it matters: It often provides high yields under mild conditions (often at room temperature or slightly cooled), reducing the need for harsh heating or extreme pH levels that might degrade sensitive molecules.

3. Racemization Suppression

The Advantage: In peptide synthesis, preserving the stereochemistry (chirality) of amino acids is critical.

Why it matters: CDI is known to cause significantly less racemization (loss of optical purity) compared to many other coupling methods. This makes it a preferred choice for synthesizing complex peptides and chiral pharmaceuticals where maintaining the specific "handedness" of the molecule is essential.

4. Versatility

The Advantage: Beyond simple amide and ester formation, CDI is versatile enough to be used for:

Synthesizing acid anhydrides.

Creating urethanes (carbamates).

Activating phosphoric acids.

Serving as a dehydrating agent in heterocycle synthesis.

Why it matters: A single reagent can handle multiple types of transformations, simplifying inventory and protocol standardization in a lab.

5. Stability and Handling

The Advantage: While it is moisture-sensitive (like most coupling agents), solid CDI is relatively stable when stored properly (in a desiccator, away from moisture).

Why it matters: It has a decent shelf life and does not decompose rapidly upon brief exposure to air compared to some more volatile or unstable reagents, making it easier to weigh and handle in a standard laboratory setting.

Common Applications

Peptide Synthesis: Joining amino acids together.

Polymer Chemistry: Modifying polymers or creating polyurethanes/polyesters.

Medicinal Chemistry: Synthesizing drug candidates where purity and stereochemistry are paramount.

Bioconjugation: Attaching labels or drugs to proteins/antibodies.

Summary:

The main selling point of 1,1'-Carbonyldiimidazole (CDI) is its ability to perform efficient coupling reactions while generating harmless, easy-to-remove byproducts and minimizing the risk of racemization, making it a "cleaner" and safer alternative to many traditional coupling agents.