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N-Acetyl-D-galactosamine (GalNAc) is a monosaccharide derivative of galactose that plays a significant role in various biological and clinical applications.
Description of N-Acetyl-D-galactosamine from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of N-Acetyl-D-galactosamine | |
Product Name | N-Acetyl-D-galactosamine 2-acetamido-2-deoxy-d-galactose |
CAS NO. | 1811-31-0 |
Apperance | White powder |
Assay | 98% |
Pacakge | 500G/1KG |
MOQ | 10g |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Fortuna |
Specifications(COA) of N-Acetyl-D-galactosamine CAS 1811-31-0 use for Diagnostic Applications Biomaterials and Tissue Engineering
Items | Standards | Results |
Appearance | White crystalline power | Positive |
Solubility | Readily soluble in water and insoluble in petrolum | Positive |
NMR and MS | Should comply | Complies |
Identification | IR and TLC | Positive |
Loss Weight On Dryness | Max. 1% | Complies |
Heavy metal | Max. 10ppm | Complies |
Assay (HPLC) | Min. 98% | 99.3% |
Conclusion | QUALIFIED. | |
N-Acetyl-D-galactosamine (GalNAc) is a monosaccharide derivative of galactose that plays a significant role in various biological and clinical applications. Some of its key applications include:
1. Glycobiology and Glycoproteins
- Glycosylation: GalNAc is crucial for the O-linked glycosylation of proteins, which occurs in the Golgi apparatus. In this process, GalNAc is attached to the serine or threonine residues of proteins, forming O-linked glycoproteins. These glycoproteins are essential for cell-cell communication, immune responses, and protein stability.
- Blood Group Antigens: GalNAc is a part of the A antigen of the ABO blood group system. It plays a role in determining an individual's blood type.
2. Therapeutic Applications
- RNAi-based Therapies: N-Acetyl-D-galactosamine (GalNAc) conjugation is used in drug delivery systems, especially in RNA interference (RNAi)-based therapies. GalNAc is conjugated to small interfering RNA (siRNA) molecules to facilitate targeted delivery to liver cells (hepatocytes). This method leverages the asialoglycoprotein receptor (ASGPR) present on hepatocytes, which has a high affinity for GalNAc, improving the drug's efficacy and reducing off-target effects.
- Targeted Drug Delivery: Apart from RNAi, GalNAc-conjugated molecules are explored for the targeted delivery of other drugs to liver cells, offering a promising approach for treating liver diseases such as hepatitis, liver cancer, and metabolic disorders.
3. Diagnostic Applications
- Lectin-Based Assays: GalNAc is utilized in lectin-based assays, where it helps in the identification and characterization of glycoproteins. This is valuable for studying various biological processes, including cancer biology, where aberrant glycosylation patterns are often observed.
- Tumor Markers: GalNAc-related glycan structures can serve as biomarkers for certain cancers, enabling the development of diagnostic tools for early cancer detection.
4. Biomaterials and Tissue Engineering
- Cellular Adhesion: GalNAc is used in the design of biomaterials that mimic natural cell environments. This can help improve cell adhesion, proliferation, and differentiation, which is beneficial in tissue engineering and regenerative medicine.
5. Immunology
- Modulation of Immune Response: The presence of GalNAc on glycoproteins and glycolipids can influence immune cell recognition and response. This property is being explored for potential applications in immunotherapy and vaccine development.
Overall, N-Acetyl-D-galactosamine has diverse applications in biotechnology, medicine, diagnostics, and research due to its unique chemical properties and biological roles.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
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