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Introduction of Vonoprazan Fumarate is a potassium-competitive acid blocker (P-CAB) used to treat acid-related disorders like GERD, peptic ulcers, and H. pylori infections. Unlike proton pump inhibitors (PPIs), it provides faster, longer-lasting acid suppression by reversibly inhibiting gastric H+/K+-ATPase.
Dosage: Typically 20 mg once daily (adjust for severe cases).
Side Effects: Mild (diarrhea, headache); rare risks include hypomagnesemia with long-term use.
Drug Interactions: Avoid with CYP3A4 inducers/inhibitors (e.g., rifampin, clarithromycin).
Pregnancy: Use cautiously (limited safety data).
Regulation: Approved in Japan, under review in US/EU.
Advantage: More effective than PPIs in refractory GERD, with rapid symptom relief.
Description of Vonoprazan fumarate from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Vonoprazan fumarate | |
Product Name | |
CAS NO. | |
Apperance | |
Assay | 99.2% |
Pacakge | 1kg/Bag, 25kg/ Box/carton |
MOQ | 1kg |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of Vonoprazan fumarate CAS 1260141-27-2
ITEMS | SPECIFICATIONS | RESULTS |
Appearance | White crystalline powder | |
Identification | The retention time of principal peak in test solution corresponds to that of reference solution | |
Loss on Drying | ≤ 0.5% | 0.1% |
Residue on Ignition | ≤0.1% | 0.08% |
Heavy Metals | ≤20ppm | ＜20ppm |
Related substance | Impurity U-2 ≤0.1% Impurity U-3 ≤0.1% Impurity U-6 ≤0.1% Impurity U-8 ≤0.1% Impurity U-9 ≤0.1% Unspecified impurity ≤0.1% | N.D 0.01% 0.01% N.D 0.005% 0.02% |
Total Impurities ≤0.5% | 0.09% | |
Residual Solvent | Methanol ≤0.3% Ethyl acetate ≤0.5% Acetic acid ≤0.5% N,N-dimethylformamide ≤0.088% Acetonitrile ≤0.041% Dichloromethane ≤0.06% N,N-diisopropylethylamine ≤0.011% | 0.01% N.D N.D N.D N.D N.D N.D |
Fumaric acid content | 23.9%~26.4% | 26.1% |
Assay | 98.0%~102.0% | 99.2% |
Conclusion | Conform | |
Introduction of Vonoprazan Fumarate is a potassium-competitive acid blocker (P-CAB) used to treat acid-related disorders like GERD, peptic ulcers, and H. pylori infections. Unlike proton pump inhibitors (PPIs), it provides faster, longer-lasting acid suppression by reversibly inhibiting gastric H+/K+-ATPase.
Dosage: Typically 20 mg once daily (adjust for severe cases).
Side Effects: Mild (diarrhea, headache); rare risks include hypomagnesemia with long-term use.
Drug Interactions: Avoid with CYP3A4 inducers/inhibitors (e.g., rifampin, clarithromycin).
Pregnancy: Use cautiously (limited safety data).
Regulation: Approved in Japan, under review in US/EU.
Advantage: More effective than PPIs in refractory GERD, with rapid symptom relief.
Application of Vonoprazan Fumarate
Definition & Mechanism
Vonoprazan fumarate is a potassium-competitive acid blocker (P-CAB) that inhibits gastric acid secretion by reversibly binding to the H⁺/K⁺-ATPase (proton pump) in stomach parietal cells. Unlike traditional proton pump inhibitors (PPIs), it does not require acid activation and provides faster, stronger, and longer-lasting acid suppression.
Gastroesophageal Reflux Disease (GERD)
Peptic Ulcers (including H. pylori eradication in combination therapy)
Gastric Acid Hypersecretion Disorders
Rapid onset (works within hours vs. days for PPIs)
Less dependency on CYP2C19 metabolism (more consistent efficacy)
Sustained acid control (effective in nocturnal acid breakthrough)
Typical dose: 20 mg once daily (may vary for H. pylori therapy)
Taken with/without food (unlike PPIs, which require pre-meal dosing)
Generally well-tolerated (common: diarrhea, nausea)
Rare risks: Hypomagnesemia (with long-term use), liver enzyme elevation
Drug interactions: Caution with CYP3A4 inhibitors/inducers (e.g., ketoconazole, rifampin)
Approved in Japan (2015), under review in US/EU
Potential future replacement for PPIs in refractory GERD
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
How do you treat quality complaint ? | |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Vonoprazan fumarate with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Vonoprazan fumarate.
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