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Holo-transferrin is the iron-loaded form of transferrin, a glycoprotein that plays a crucial role in the transport and distribution of iron throughout the body. The term "holo" refers to the protein being fully saturated with iron, typically binding two ferric ions (Fe³⁺). The applications of holo-transferrin are diverse, particularly in biomedical research and clinical settings.
Description of Holo-transferrin from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Holo-transferrin | |
Product Name | Holo-transferrin |
CAS NO. | 11096-37-0 |
Apperance | Red freeze-dried powder |
Assay | 99% |
Pacakge | 1G/10G/100G/Bag |
MOQ | 1G |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Watson |
Applications of Holo-transferrin CAS11096-37-0 use for Cell Culture and Diagnostic Imaging
Holo-transferrin is the iron-loaded form of transferrin, a glycoprotein that plays a crucial role in the transport and distribution of iron throughout the body. The term "holo" refers to the protein being fully saturated with iron, typically binding two ferric ions (Fe³⁺). The applications of holo-transferrin are diverse, particularly in biomedical research and clinical settings. Here are some key applications:
1. Cell Culture:
-*Iron Source: Holo-transferrin is commonly used as a source of iron in cell culture media. Many cell types, especially those that are difficult to culture, require a stable and bioavailable iron source to proliferate and function properly.
- Serum-Free Media:It is often added to serum-free media formulations to ensure that cells have the necessary iron for various metabolic processes without the need for serum.
2. Iron Metabolism Studies:
- Research Tool: Holo-transferrin is used in studies related to iron metabolism, transport, and storage. It helps researchers understand the mechanisms of iron uptake by cells, particularly through transferrin receptors.
- Receptor Studies: It is utilized to study the expression, regulation, and function of transferrin receptors, which are key players in iron homeostasis.
3. Drug Delivery Systems:
- Targeted Delivery: Holo-transferrin can be used in the development of drug delivery systems. For example, it can be conjugated to drugs or nanoparticles to target cells that overexpress transferrin receptors, such as certain cancer cells, enhancing the specificity and efficacy of treatments.
- Cancer Therapy: Because many cancer cells have elevated transferrin receptor levels, holo-transferrin is explored in targeted cancer therapies to deliver cytotoxic agents specifically to tumor cells.
4.Diagnostic Imaging:
- Radiolabeling: Holo-transferrin can be radiolabeled and used in imaging techniques, such as positron emission tomography (PET) or magnetic resonance imaging (MRI), to visualize tumors or study iron distribution in the body.
- Iron Deficiency Anemia: It is used in diagnostic tests to assess iron-binding capacity and transferrin saturation, which are important parameters in the diagnosis of iron deficiency anemia.
5. Therapeutic Uses:
- Iron Overload Disorders: While more common with apo-transferrin (the iron-free form), holo-transferrin is also being explored in the treatment of certain iron overload disorders to modulate iron distribution in the body.
- Neurodegenerative Diseases:It is being investigated for potential therapeutic applications in neurodegenerative diseases where iron dysregulation is implicated, such as Alzheimer's disease or Parkinson's disease.
These applications highlight the versatility of holo-transferrin in both research and clinical contexts, especially in areas related to iron metabolism, targeted therapy, and diagnostics.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
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