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Cortexolone, also known as 11-Deoxycortisol, is primarily an intermediate in the production of cortisol in the adrenal glands. While cortexolone itself is not typically used directly for therapeutic applications, it is a precursor in biochemical and medical research, particularly in endocrinology. Additionally, its derivative, cortexolone 17α-propionate (known as clascoterone), has gained attention in clinical applications.
Description of Cortexolone from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Cortexolone | |
Product Name | Cortexolone |
CAS NO. | 152-58-9 |
Appearance | White powder |
Assay | 98% |
Package | 1kg/bag;25kg/Drum |
Brand | Fortunachem |
Cortexolone, also known as 11-Deoxycortisol, is primarily an intermediate in the production of cortisol in the adrenal glands. While cortexolone itself is not typically used directly for therapeutic applications, it is a precursor in biochemical and medical research, particularly in endocrinology. Additionally, its derivative, cortexolone 17α-propionate (known as clascoterone), has gained attention in clinical applications.
Applications of Cortexolone and Its Derivatives
Biochemical Research in Endocrinology:
Cortisol Synthesis Pathway: Cortexolone is a key steroid intermediate in cortisol biosynthesis, so it is widely used in research to study the effects of enzyme deficiencies and adrenal function.
Diagnostic Testing: Cortexolone can be measured in clinical diagnostics to assess adrenal gland function, aiding in the diagnosis of disorders such as congenital adrenal hyperplasia (CAH).
Development of Anti-Androgenic Compounds (e.g., Clascoterone):
Acne Treatment: Clascoterone, a synthetic derivative of cortexolone, is approved as a topical anti-androgen for treating acne. It works by blocking androgen receptors in the skin, thereby reducing sebum production and inflammation that contribute to acne.
Treatment for Androgenic Alopecia: Clascoterone has also been investigated for treating androgenic alopecia (hair loss) as it can potentially prevent the effects of androgens on hair follicles.
Study of Steroid Metabolism Disorders:
Researchers use cortexolone to investigate the pathways of steroid synthesis and metabolic disorders affecting steroid production, especially in adrenal diseases. This research is instrumental in developing treatments for these disorders.
Potential New Therapeutic Pathways:
Cortexolone and its analogs are subjects of research for potential anti-inflammatory and anti-cancer therapies due to their influence on hormonal pathways.
Summary
While cortexolone itself has limited direct therapeutic applications, its derivative clascoterone is widely used for dermatological purposes. Cortexolone also plays an important role in research related to adrenal steroid synthesis and is essential in studying and diagnosing hormonal imbalances and adrenal disorders.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Cortexolone with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Cortexolone.
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