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Folinic acid, also known as leucovorin, is a form of folate (vitamin B9) that is used in various medical applications. It is not the same as folic acid but rather a metabolically active derivative.
Description of Folinic Acid from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Folinic Acid | |
Product Name | Folinic Acid |
CAS NO. | 58-05-9 |
Apperance | Off-white to greenish yellow powder,no visible impurities. |
Assay | 99% |
Pacakge | 1kg/Foil Bag,25kg/Drum/Box |
MOQ | 1kg |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Fortuna |
Specifications(COA) of Folinic Acid CAS 58-05-9
ITEMS | SPECIFICATIONS | RESULTS |
Appearance | Off-white to greenish yellow powder,no visible impurities. | Conform |
Identification (HPLC) | The main peak RT is the same with that of the standard | Conform |
Heavy metals | ≤50ppm | Conform |
Water content | ≤12.0% | 9.9% |
Specific optical rotation | +14.5° ～+20.5° | +15.4° |
Related substance | Individual impurity ≤1.0% | 0.2% |
Total impurities ≤2.5% | 0.4% | |
Purity | ≥97.5% | 99.6% |
Conclusion | QUALIFIED. | |
Folinic acid, also known as leucovorin, is a form of folate (vitamin B9) that is used in various medical applications. It is not the same as folic acid but rather a metabolically active derivative. The main applications of folinic acid include:
### 1. **Chemotherapy Support (Methotrexate Rescue)**
- **Methotrexate Toxicity Rescue:** Methotrexate is a chemotherapy drug that can be toxic to healthy cells as it inhibits folate metabolism. Folinic acid helps "rescue" normal cells by providing them with a form of folate they can use, thereby reducing methotrexate's toxic side effects.
- **Enhancing Chemotherapy (5-Fluorouracil):** Folinic acid is often used alongside the chemotherapy drug 5-fluorouracil (5-FU). It enhances the effectiveness of 5-FU by stabilizing the bond between the drug and the target enzyme (thymidylate synthase), thereby improving its cancer-fighting ability.
### 2. **Megaloblastic Anemia**
- Folinic acid is used to treat megaloblastic anemia when it results from folate deficiency, especially in people who have trouble converting folic acid to its active form, such as those with genetic defects (e.g., MTHFR mutation).
### 3. **Overdose of Folic Acid Antagonists**
- Folinic acid is used to treat overdoses of folic acid antagonists like pyrimethamine and trimethoprim, which are found in certain medications (e.g., antibiotics and antiparasitics).
### 4. **Neurological Disorders**
- It is used in some cases to manage or improve neurological function in conditions like cerebral folate deficiency or neurodegenerative diseases. Some research also suggests it may be beneficial in conditions such as autism spectrum disorders, though more studies are needed.
### 5. **Pernicious Anemia**
- Though vitamin B12 is typically used to treat pernicious anemia, folinic acid may be used in combination in certain cases where there's a combined folate deficiency.
These are the main medical applications of folinic acid, especially in managing the toxic effects of certain drugs and supporting folate metabolism in specific conditions.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Folinic Acid with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Folinic Acid.
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