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5-Methyluridine, also known as ribothymidine or m^5U, is a nucleoside that consists of the nitrogenous base thymine attached to a ribose sugar. It is a modified form of the nucleoside uridine, in which a methyl group is added to the 5th carbon of the uracil base.
Structure: 5-Methyluridine has the chemical structure similar to uridine, except for the methyl group at the 5th position of the uracil ring.
Chemical Formula: C10H14N2O6.
Role in Biology: 5-Methyluridine is typically found in transfer RNA (tRNA) and plays a role in the proper folding and function of tRNA molecules during protein synthesis.
Synthesis and Modifications: It is one of the many modified nucleosides that are formed post-transcriptionally in RNA molecules, adding to the diversity and functionality of RNA structures.
Specifications of 5-Methyluridine CAS 1463-10-1 COA:
Items | Specifications | Results |
Appearance | White to off white crystalline powder | White powder |
Residue on ignition | ≤0.1% | 0.04% |
Loss on drying | ≤0.5% | 0.1% |
Identification（HPLC） | RT Consistent to Reference | Conform |
Purity(HPLC) | ≥99.0% | 99.85% |
Impurity % | ≤0.5% | 0.1% |
Total Impurity % | ≤1.0% | 0.15% |
Assay | ≥98.5% | 99.59% |
Conclusion | The product conforms to the above specifications. | |
CAS:1463-10-1
MF:C10H14N2O6
Melting point :183-184 °C(lit.)
form:powder
color:White crystalline
Uses:
5-Methyluridine (m⁵U) has several applications, particularly in the fields of biochemistry, molecular biology, and medicine. Here are some of its primary applications:
### 1. **Biological Research:**
- **RNA Studies**: 5-Methyluridine is commonly used in research to study the structure, function, and modifications of RNA. Because it is naturally found in tRNA, it is often used to understand RNA stability, folding, and the impact of chemical modifications on RNA behavior.
- **tRNA Functionality**: It is involved in studies of translation and protein synthesis, as 5-methyluridine is a component of tRNA, helping researchers understand codon-anticodon interactions and the role of modified bases in tRNA recognition.
### 2. **Chemical Synthesis:**
- **Synthesis of Oligonucleotides**: 5-Methyluridine is sometimes used in the chemical synthesis of modified oligonucleotides, which are important tools in genetic research and therapeutic applications. Modified oligonucleotides with 5-methyluridine can be used to study RNA stability and the effects of methylation on RNA-DNA hybridization.
### 3. **Therapeutic Applications:**
- **Potential Drug Development**: Modified nucleosides, including 5-methyluridine, are of interest in the development of antiviral and anticancer drugs. They can be used as building blocks in the synthesis of nucleoside analogs that have potential therapeutic effects.
- **Epigenetic Studies**: Because 5-methyluridine represents a methylated nucleotide, it can be useful in the study of epigenetic regulation, particularly in the context of RNA modification and methylation.
### 4. **Pharmaceutical and Nutritional Supplements:**
- **Health Supplements**: Nucleosides like 5-methyluridine are sometimes used in health supplements to promote cellular health, improve cognitive function, or provide nutritional support in certain health conditions.
### 5. **Biomarker for Disease and Cellular Health:**
- **Biomarker Research**: 5-Methyluridine, along with other modified nucleosides, can serve as a potential biomarker for various diseases. The presence and levels of such modified nucleosides in biological fluids like urine can provide information about cellular turnover and disease states, such as cancer.
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A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
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A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
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Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide 5-Methyluridine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of 5-Methyluridine.
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