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Introduction of Rink Amide Linker.
The Rink Amide Linker is a widely used chemical linker in solid-phase peptide synthesis (SPPS). It was developed by Hans Rink in the 1980s and has since become a standard tool in the field of peptide chemistry. The Rink Amide Linker is particularly valued for its ability to facilitate the synthesis of C-terminal amide peptides, which are common in biologically active peptides.
Key Features of the Rink Amide Linker:
Cleavage Conditions: The Rink Amide Linker is designed to be cleaved under mildly acidic conditions, typically using trifluoroacetic acid (TFA). This allows for the release of the synthesized peptide from the solid support while preserving the integrity of the peptide.
Stability: The linker is stable under the basic conditions used during the peptide elongation process, which involves repeated cycles of deprotection and coupling reactions.
Amide Formation: Upon cleavage, the Rink Amide Linker generates a C-terminal amide group on the peptide. This is particularly useful because many natural peptides and therapeutic peptides have a C-terminal amide, which can be important for their biological activity and stability.
Solid Support: The linker is typically attached to a polystyrene resin, which serves as the solid support for the peptide synthesis. The resin-bound linker provides a convenient handle for the growing peptide chain.
Description of Rink Amide Linker from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Rink Amide Linker | |
Product Name | Rink Amide Linker |
CAS NO. | 145069-56-3 / 126828-35-1 |
Apperance | White powder |
Assay | 99%min |
Pacakge | 1kg/Foil Bag,25kg/Drum/Box |
MOQ | 1kg |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of High Purity Rink Amide Linker Powder CAS NO 145069-56-3 / 126828-35-1 Biochemical Peptide Chemistry with Good Price
Items | Specifications | Results |
Appearance | White powder | Conforms |
Purity(HPLC) | ≥99.0% | Conforms |
Melting point | 176.0-186.0℃ | Conforms |
Loss on drying | ≤1.0% | Conforms |
Clarity | Clear and Transparent(0.3g in 2ml DMF) | Conforms |
Identification by Mass | Conforms to Structure | Conforms |
Conclusion | The product conforms to the standard of CP2010. | |
Introduction of Rink Amide Linker.
The Rink Amide Linker is a widely used chemical linker in solid-phase peptide synthesis (SPPS). It was developed by Hans Rink in the 1980s and has since become a standard tool in the field of peptide chemistry. The Rink Amide Linker is particularly valued for its ability to facilitate the synthesis of C-terminal amide peptides, which are common in biologically active peptides.
Key Features of the Rink Amide Linker:
Cleavage Conditions: The Rink Amide Linker is designed to be cleaved under mildly acidic conditions, typically using trifluoroacetic acid (TFA). This allows for the release of the synthesized peptide from the solid support while preserving the integrity of the peptide.
Stability: The linker is stable under the basic conditions used during the peptide elongation process, which involves repeated cycles of deprotection and coupling reactions.
Amide Formation: Upon cleavage, the Rink Amide Linker generates a C-terminal amide group on the peptide. This is particularly useful because many natural peptides and therapeutic peptides have a C-terminal amide, which can be important for their biological activity and stability.
Solid Support: The linker is typically attached to a polystyrene resin, which serves as the solid support for the peptide synthesis. The resin-bound linker provides a convenient handle for the growing peptide chain.
Application of Rink Amide Linker.
The Rink Amide Linker is primarily used in solid-phase peptide synthesis (SPPS) to produce peptides with a C-terminal amide group. This specific modification is crucial for many peptides’ biological activity, stability, and overall function. Here are some key applications of the Rink Amide Linker:
1. Peptide Therapeutics:
Drug Development: Many therapeutic peptides require a C-terminal amide for their biological activity. The Rink Amide Linker facilitates the synthesis of these peptides, making it a valuable tool in the development of peptide-based drugs.
Stability and Bioavailability: C-terminal amides can enhance the stability and bioavailability of peptides, making them more effective as therapeutic agents.
2. Biological Research:
Protein-Protein Interactions: Researchers use peptides synthesized with the Rink Amide Linker to study interactions between proteins, which can provide insights into cellular processes and disease mechanisms.
Enzyme Substrates: Peptides with C-terminal amides are often used as substrates in enzymatic assays to study enzyme activity and specificity.
Receptor Ligands: Many receptors in the body recognize and bind to peptides with specific C-terminal modifications, including amides. Synthesizing these peptides helps in studying receptor-ligand interactions.
3. Custom Peptide Synthesis:
Research and Development: Laboratories and commercial peptide synthesis services use the Rink Amide Linker to produce custom peptides tailored to specific research needs, including those with C-terminal amides.
Peptide Libraries: The linker is used to create libraries of peptides with diverse sequences and modifications for high-throughput screening in drug discovery and other research applications.
4. Diagnostic Tools:
Biomarker Discovery: Peptides synthesized with the Rink Amide Linker can be used in assays to identify and quantify biomarkers for various diseases.
Immunoassays: These peptides can serve as antigens or epitopes in immunoassays, aiding in the detection of antibodies or other proteins of interest.
5. Vaccine Development:
Epitope Mapping: Peptides with C-terminal amides are used to map epitopes, which are the parts of antigens recognized by the immune system. This is crucial for designing effective vaccines.
6. Peptide-Based Materials:
Biomaterials: Peptides synthesized with the Rink Amide Linker can be used to create biomaterials with specific properties for applications in tissue engineering and regenerative medicine.
7. Peptide Conjugates:
Drug Delivery: Peptides with C-terminal amides can be conjugated to other molecules, such as drugs, imaging agents, or nanoparticles, to improve targeting and delivery to specific cells or tissues.
In summary, the Rink Amide Linker is a versatile tool in peptide chemistry, enabling the synthesis of peptides with C-terminal amides that are essential for a wide range of applications in therapeutics, research, diagnostics, and materials science.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
Q | How do you treat quality complaint ? |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Rink Amide Linker with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Rink Amide Linker.
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