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Stavudine (d4T) is an antiretroviral medication classified as a nucleoside reverse transcriptase inhibitor (NRTI), used to treat HIV/AIDS. It works by blocking viral replication. Once widely used due to its affordability and efficacy, stavudine is now largely phased out globally because of severe long-term toxicities, including mitochondrial toxicity, lipodystrophy (fat redistribution), peripheral neuropathy, and lactic acidosis. The World Health Organization (WHO) recommends avoiding stavudine in first-line regimens, prioritizing safer alternatives like tenofovir or abacavir. Its use persists only in limited resource settings where alternatives are unavailable, emphasizing the need for strict clinical monitoring to mitigate risks.
Description of Stavudine from Wuhan Fortuna Chemical Co.,Ltd
Basic Information of Stavudine | |
Product Name | Stavudine |
CAS NO. | 3056-17-5 |
Apperance | White crystall powder |
Assay | ≥98.0% |
Pacakge | 25kg/Drum |
MOQ | 1kg |
Storage | Cool and dry place |
Shelf Life | 2 Years |
Brand | Fortunachem |
Specifications(COA) of Stavudine CAS 3056-17-5
ITEMS | SPECIFICATIONS | RESULTS |
Appearance | White crystall powder | Conform |
Identification | Conform | Conform |
Water | ≤1.0% | 0.26% |
Related substances | Max single purity≤0.5% | 0.04% |
Purity | ≥99.0% | 99.9% |
Assay | ≥98.0% | 99.5% |
Conclusion | Complies with USP37 standard. | |
What is Stavudine ?
Stavudine (d4T) is an antiretroviral medication classified as a nucleoside reverse transcriptase inhibitor (NRTI), used to treat HIV/AIDS. It works by blocking viral replication. Once widely used due to its affordability and efficacy, stavudine is now largely phased out globally because of severe long-term toxicities, including mitochondrial toxicity, lipodystrophy (fat redistribution), peripheral neuropathy, and lactic acidosis. The World Health Organization (WHO) recommends avoiding stavudine in first-line regimens, prioritizing safer alternatives like tenofovir or abacavir. Its use persists only in limited resource settings where alternatives are unavailable, emphasizing the need for strict clinical monitoring to mitigate risks.
What is the application of Stavudine?
Stavudine, also known as d4T, is a nucleoside reverse transcriptase inhibitor (NRTI) used primarily in the treatment of HIV infection. Its applications include:
1.HIV Treatment: Stavudine is part of combination antiretroviral therapy (ART) to manage HIV infection. It works by inhibiting the reverse transcriptase enzyme,
preventing the virus from replicating.
2. Prevention of Mother-to-Child Transmission: It can be used to reduce the risk of HIV transmission from mother to child during pregnancy, labor, and delivery.
3.Post-Exposure Prophylaxis (PEP): In some cases, stavudine may be included in PEP regimens to prevent HIV infection after potential exposure.
4.Resource-Limited Settings: Due to its lower cost, stavudine has been widely used in developing countries, although its use has declined due to associated side effects.
Important Considerations:
Side Effects: Stavudine can cause significant side effects, including peripheral neuropathy, lipodystrophy, and lactic acidosis.
Resistance: As with other antiretrovirals, resistance can develop, necessitating careful management and combination with other drugs.
Guidelines: Its use is now limited in many guidelines due to the availability of safer alternatives.
Stavudine has played a crucial role in HIV management, especially in resource-limited settings, but its use is now more restricted due to its side effect profile.
FAQ From Wuhan Fortuna Chemical Co.,Ltd | |
Q | Can I get a sample for free ? |
A | For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test. |
Q | How to confirm the product quality before placing orders ? |
A | Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order. |
Q | What is the payment you accept? |
A | For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us. |
Q | What is your shipment way ? |
A | For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement. |
Q | How long is your after-sales service? |
A | We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company. |
How do you treat quality complaint ? | |
A | We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers. |
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Stavudine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Stavudine CAS 3056-17-5.
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