Name: China Supplier Hot Selling Wholesale Price L(+)-Homoarginine Hydrochloride CAS 1483-01-8
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of L(+)-Homoarginine Hydrochloride CAS 1483-01-8

Items	Specification	Result
Appearance	White to off-white crystalline powder	White crystalline powder
Assay	98.0%-101.5%	99.0%
Loss on drying	≤0.2%	0.1%
Residue on ignition	≤0.1%	0.06%
Heavy metals	≤10ppm	<10ppm

Parameters of L(+)-Homoarginine Hydrochloride CAS 1483-01-8

Product parameters
Cas number:	1483-01-8
Appearance:	White to off-white crystalline powder
Purity:	98.0%-101.5%
MOQ:	1kg
Price:	Negotiable
Package details:	100g, 1kg/foil bag
Brand:	Fortunachem

L(+)-Homoarginine hydrochloride is a chemically modified, salt form of the non-proteinogenic amino acid homoarginine. Its structure and properties are as follows:

Chemical Structure:

Homoarginine: This is a basic amino acid that is structurally analogous to the canonical amino acid L-arginine. The key difference is the addition of a single methylene group (-CH₂-) in its side chain. Specifically, while arginine has a guanidino group attached directly to a carbon chain, homoarginine has the guanidino group attached via an additional -CH₂- unit, effectively making its side chain one carbon longer.
L(+)-: This notation specifies the stereochemistry. The "L" refers to the specific three-dimensional configuration around the chiral alpha-carbon atom, which is the same as that found in the natural, biologically active L-amino acids. The "(+)" indicates that this enantiomer is dextrorotatory, meaning it rotates the plane of plane-polarized light in a clockwise direction.
Hydrochloride (HCl): This indicates the molecule is in a salt form, where the strongly basic guanidino group has been protonated and paired with a chloride counterion (Cl⁻). This form enhances the compound's stability, crystallinity, and solubility in aqueous solutions.

Key Characteristics and Applications:

Biochemical Tool: Homoarginine is not commonly incorporated into proteins during ribosomal synthesis. Instead, it is primarily used as a research tool in biochemical and physiological studies.
Role in Nitric Oxide (NO) Pathway: Its primary significance lies in its interaction with the Nitric Oxide Synthase (NOS) enzyme family.

It acts as an alternative substrate for NOS. However, it is typically a less efficient or "weaker" substrate compared to its native counterpart, L-arginine.
Because of this, it can function as a mild competitive inhibitor of NOS. By occupying the enzyme's active site, it can reduce the production of Nitric Oxide from L-arginine, allowing researchers to probe the enzyme's function and the role of NO in various processes like vasodilation, neurotransmission, and immune response.

Biomarker Potential: Low levels of endogenous L-homoarginine in plasma have been investigated as a potential biomarker associated with an increased risk of cardiovascular diseases and mortality.

In summary, L(+)-Homoarginine hydrochloride is a stable, synthetic amino acid derivative that serves as a crucial pharmacological and research tool for studying the complex roles of the nitric oxide pathway in health and disease.