Name: China Manufacturer High Quality Best Price Sodium Salicylate CAS 54-21-7
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Sodium Salicylate CAS 54-21-7

Items	Specifications	Results
Characters	A white,or almost white,crystalline powder or small,colourless crystals or shiny flakes,freely soluble in water,sparingly soluble in ethanol(96%)	Complies
Identification	Sample Infrared absorption spectropho-tometry Complies Sodium salicylate CRS.	Complies
	Gives the reactions of salicylates	Positive
	Gives reaction (b) of sodium	Positive
Appearance of solution	The solution is clear and not more intensely coloured than reference solution BY6.	The solution is clear and not more intensely coloured than reference solution BY6.
Acidity	0.01M NaOH not more than 2.0ml is required	0.88ml
Chlorides	≤200ppm	＜200ppm
Sulfates	≤600ppm	＜600ppm
Heavy metals	≤20ppm	＜20ppm
Loss on drying	≤0.50%	0.04%
Assay(dried substance)	ContainsC₇H₅NaO₃99.0% to 101.0%	99.6%
Conclusion	The product comply with the requirements of BP2022.

Parameters of Sodium Salicylate CAS 54-21-7

Product parameters
Cas number:	54-21-7
Appearance:	White crystalline powder
Purity:	99~101%
Package details:	25kg/bag
Brand:	Fortunachem

Sodium salicylate is the sodium salt of salicylic acid. It is an organic compound with the formula C₇H₅NaO₃.

In simpler terms, it's formed when the acidic hydrogen (H) on the -OH group of salicylic acid is replaced by a sodium ion (Na⁺).

1. Chemical Structure and Formation

Parent Compound: Salicylic Acid (C₇H₆O₃)

It has a benzene ring with two functional groups: a carboxylic acid group (-COOH) and an ortho-positioned phenolic hydroxyl group (-OH).
The -COOH group is acidic.

Formation Reaction:
Salicylic acid reacts with a base, such as sodium hydroxide (NaOH), in a neutralization reaction. The hydrogen from the carboxylic acid group is replaced by a sodium ion.
Chemical Equation:
C₆H₄(OH)COOH + NaOH → C₆H₄(OH)COONa + H₂O
(More precisely: C₆H₄(OH)COO⁻ H⁺ + Na⁺ OH⁻ → C₆H₄(OH)COO⁻ Na⁺ + H₂O)
Molecular Structure:

2. Key Chemical Properties

Appearance: A white, crystalline, odorless powder.
Solubility: It is highly soluble in water and polar solvents like glycerol. This is a key difference from salicylic acid, which is poorly soluble in water. The ionic nature of the salt allows it to dissolve easily in polar water molecules.
pH: Its aqueous solution is slightly basic to neutral (pH ~6-7) because the conjugate base of a weak acid (salicylic acid) hydrolyzes water slightly.
Melting Point: It decomposes upon heating rather than having a clear melting point.

3. How it Works in the Body (Pharmacology)

Sodium salicylate is a key metabolite of aspirin (acetylsalicylic acid) in the human body. While aspirin itself inhibits cyclooxygenase (COX) enzymes to exert its effects, sodium salicylate has a different and more complex mechanism:

Primary Mechanism: It is a weak anti-inflammatory and analgesic (pain-reliever). Its main action is not strong COX inhibition like aspirin. Instead, it is believed to work by suppressing the expression of the COX-2 enzyme at the genetic level (by inhibiting transcription factors like NF-κB). This means it prevents the body from producing more of the enzyme that causes inflammation and pain, rather than just blocking the existing enzyme.
Antipyretic: It also has antipyretic (fever-reducing) effects, likely through action on the hypothalamus in the brain.

4. Common Uses

Medicinal:

Analgesic and Anti-pyretic: Historically used to treat pain, fever, and inflammatory conditions like rheumatic fever and arthritis. Its use has largely been replaced by newer NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) like ibuprofen, which have a better safety profile.
Prodrug: As the active metabolite of aspirin, it is responsible for a significant portion of aspirin's long-lasting effects.

Industrial and Laboratory:

Precursor: Used in the organic synthesis of other chemicals.
Analytical Chemistry: Sometimes used as a standard or reagent.
Preservative: In some cosmetics and personal care products due to its mild antimicrobial properties.

Comparison with Salicylic Acid

Feature	Sodium Salicylate	Salicylic Acid
Chemical Formula	C₇H₅NaO₃	C₇H₆O₃
Form	Sodium Salt	Organic Acid
Solubility in Water	High	Low
Primary Medicinal Use	Systemic (pain, fever)	Topical (acne, warts, psoriasis)
pKa	N/A (it's a salt)	~2.97 (acidic)

Summary

In chemical terms, sodium salicylate is the water-soluble sodium salt of salicylic acid. It is an ionic organic compound known for its role in medicine as a pain reliever, fever reducer, and anti-inflammatory agent, primarily through a mechanism that suppresses inflammation-related gene expression.