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Spironolactone is used to treat high blood pressure and heart failure.
Spironolactone is a competitive inhibitor of aldosterone, the drug itself is not active, the diuretic effect is competitive antagonism with endogenous aldosterone, belongs to potassium-sparing diuretics. (1) Edema disease, which is combined with other diuretics to treat edematous diseases such as congestive heart failure, cirrhosis ascites, renal edema, etc., with the aim of correcting the secondary increased secretion of aldosterone associated with the above diseases and against the potassium excretion effect of other diuretics; It is also used in the treatment of idiopathic edema. (2) Hypertension, which is used as an adjuvant treatment for hypertension. (3) Primary aldosteronism, spironolactone can be used for the diagnosis and treatment of this disease. (4) Prevention of hypokalemia, which is combined with thiazide diuretics to enhance diuretic effect and prevent hypokalemia.
| Item | Specifications | Results |
| Appearance | White or almost white crystalline powder | Conform |
| Loss on drying | ≤0.5% | 0.1% |
| Assay | 97.0% - 103.0% | 100.9% |
| Product parameters | |
| Cas number: | 52-01-7 |
| Appearance: | white or yellowish-white powder |
| Purity: | 97.0% - 103.0% |
| Package details: | 1kg/bag,25kg/drum |
| Brand: | Fortunachem |
Spironolactone is a prescription medication primarily known as a potassium-sparing diuretic (water pill). Its key action is blocking the hormone aldosterone, which regulates salt and water balance.
Heart Failure: Used to reduce fluid buildup (edema) and improve survival by counteracting harmful effects of aldosterone.
Hypertension (High Blood Pressure): Often used in combination with other diuretics to lower blood pressure while preventing potassium loss.
Liver Disease (Cirrhosis): Treats dangerous fluid retention (ascites) in the abdomen.
Hormonal & Dermatological Conditions (Off-label):
PCOS (Polycystic Ovary Syndrome): Manages symptoms like hirsutism (excess hair growth) and acne by blocking androgen (male hormone) receptors.
Acne & Female-Pattern Hair Loss: Frequently prescribed for its anti-androgen effects.
Side Effects: Can include high potassium levels (hyperkalemia), dizziness, breast tenderness, and menstrual irregularities.
Warning: It is a teratogen and can cause feminization of a male fetus; reliable contraception is required for women of childbearing age.
Availability: It is only available by prescription due to its potent effects and monitoring requirements.
In summary, spironolactone is a versatile drug essential for managing cardiovascular and liver-related fluid retention, and it is also a cornerstone treatment for androgen-driven conditions in women.
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