Name: China Factory Supply Good Service Tazarotene CAS 118292-40-3
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Tazarotene CAS 118292-40-3

Items	Specification	Result
Assay(HPLC)	98.5%-101.5%	99.6%
Appearance	White to light yellow crystal or crystalline powder	Conform
Melting point	102-105℃	103℃
Loss on drying	≤1.0%	0.1%
Residue on ignition	≤0.1%	<0.1%
Heavy metals	≤20ppm	<20ppm
Substance by HPLC	Single biggest impurity≤0.5% Total impurities≤1.0%	<0.1% 0.1%

Parameters of Tazarotene CAS 118292-40-3

Product parameters
Cas number:	118292-40-3
Appearance:	White to light yellow crystal or crystalline powder
Purity:	98.5%-101.5%
Package details:	1g/foil bag
Brand:	Fortunachem

Tazarotene is a prescription-only topical medication belonging to a class of drugs called retinoids. It is a synthetic derivative of Vitamin A and is known for its potency and effectiveness in treating various skin conditions.

It is most commonly sold under the brand names:

Tazorac (gel and cream)
Arazlo (a newer, lower-concentration lotion formulated to be gentler)
Fabior (foam)

Primary Uses and How It Works

Tazarotene works primarily by influencing the growth and development of skin cells. Its main mechanisms of action are:

Normalizing Skin Cell Growth: It helps to regulate the process of keratinization (the life cycle of skin cells), preventing them from becoming overly sticky and clogging pores.

Reducing Inflammation: It has potent anti-inflammatory properties.

Increasing Cell Turnover: It promotes the shedding of dead skin cells and the generation of new, healthy ones.

Because of these actions, it is prescribed for:

Acne (Vulgaris): It is highly effective for treating both comedonal (blackheads and whiteheads) and inflammatory acne (papules and pustules). It unclogs pores and reduces the redness and swelling of existing pimples.
Plaque Psoriasis: It helps to slow down the rapid production of skin cells that leads to the formation of raised, red, scaly plaques characteristic of this condition.
Photoaging: It is widely used "off-label" to treat fine wrinkles, mottled hyperpigmentation (sun spots), and surface roughness caused by sun damage. It improves skin texture and tone by promoting collagen production and exfoliation.

Important Considerations and Potential Side Effects

Tazarotene is a powerful medication, and its use comes with important considerations.

Common Side Effects:
These are often most noticeable during the first 2-4 weeks of use (the "retinization" or adjustment period) and typically improve with continued use. They include:

Skin Irritation: Redness, dryness, itching, stinging, and burning at the application site.
Peeling and Flaking: This is a sign of increased cell turnover.
Skin Sensitivity: Increased sensitivity to sunlight (photosensitivity).

To manage these side effects:

Start Slowly: Your dermatologist will likely advise you to start applying it every other night or even just 2-3 times a week to allow your skin to adjust.
Use a Pea-Sized Amount: A tiny amount is enough for the entire face.
Moisturize: Apply a good, non-comedogenic moisturizer daily to combat dryness.
Sun Protection is NON-NEGOTIABLE: Your skin will be much more susceptible to sunburn. Daily use of a broad-spectrum sunscreen with SPF 30 or higher is absolutely essential.

Who Should NOT Use Tazarotene?

Pregnancy (Category X): Tazarotene is contraindicated in pregnancy. It has been shown to cause fetal harm and birth defects. Women of childbearing age must use effective contraception while using this medication.
Breastfeeding: It is not known if tazarotene passes into breast milk. Consultation with a doctor is essential.
Individuals with Eczema or Severely Sensitive Skin: It can cause severe irritation.
Those with a Known Hypersensitivity: To tazarotene or any of its ingredients.

Tazarotene vs. Other Retinoids (Like Tretinoin)

Strength: Tazarotene is generally considered more potent and faster-acting than tretinoin for both acne and psoriasis.
Irritation: Because it is more potent, it also has a higher potential for causing irritation, dryness, and peeling, especially upon starting.
Formulation: Newer formulations like Arazlo (lotion) are specifically designed to deliver the efficacy of tazarotene with a significantly reduced risk of irritation.

Key Takeaway

Tazarotene is a highly effective prescription retinoid for treating severe acne, psoriasis, and sun damage. However, due to its potency and potential for side effects, it must be used under the strict guidance of a dermatologist or healthcare provider who can determine the correct strength and application frequency for your specific skin condition and type.