Name: China Factory Supply High Quality 2-Adamantanone CAS 700-58-3 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of 2-Adamantanone CAS 700-58-3

Items	Specifications	Results
Appearance	Off-white to white solid	Conforms
Purity	≥98.0%	99.6%
Water	≤0.5%	0.1%
Conclusion	The product conforms to the above specifications.

Parameters of 2-Adamantanone CAS 700-58-3

Product parameters
Cas number:	700-58-3
Appearance:	White or gray white crystal
Purity:	99.0%min
Package details:	25kg/bag, 25kg/drum
Brand:	Fortunachem

2-Adamantanone is an organic compound with the molecular formula C₁₀H₁₄O. It is a ketone derivative of adamantane, where a carbonyl group (C=O) is attached to the bridgehead carbon at position 2 of the adamantane cage.

Structure: Imagine the rigid, three-dimensional, diamond-like cage structure of adamantane (a cycloalkane with 10 carbon atoms). 2-Adamantanone is formed by replacing one of the hydrogen atoms on a specific carbon (the "bridgehead") with an oxygen atom, creating a ketone functional group.

Key Properties:

White crystalline solid at room temperature.
Possesses the high chemical and thermal stability characteristic of the adamantane skeleton.
The carbonyl group makes it a versatile intermediate for chemical synthesis, as it can undergo various reactions (reductions, Grignard reactions, etc.) to introduce other functional groups onto the robust adamantine core.

Primary Uses and Applications

2-Adamantanone's main value lies not in direct application, but as a crucial building block (synthon) in organic and medicinal chemistry. Its rigid, lipophilic (fat-soluble) structure is highly desirable for designing pharmaceutical agents.

1. Pharmaceutical Intermediates (Most Significant Use)

It is a key precursor in the synthesis of several important drugs and bioactive molecules. The adamantane moiety often enhances lipid solubility, metabolic stability, and binding affinity to biological targets.

Adapalene: A topical retinoid used to treat acne. 2-Adamantanone is a starting material in its synthesis.
Saxagliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor used for type 2 diabetes.
Antiviral Agents: Derivatives of adamantane, such as amantadine and rimantadine (used against influenza A), share the same core structure. While not made directly from the ketone, 2-adamantanone is used to create novel analogs and more complex derivatives with potential antiviral, antibacterial, or neuroprotective activity.
Other Drug Candidates: It serves as a scaffold for developing potential treatments for neurological disorders (e.g., Parkinson's, Alzheimer's) and various other conditions.

2. Material Science & Polymer Chemistry

High-Performance Polymers: Incorporated into polymer backbones to create materials with enhanced thermal stability, rigidity, and solubility. These polymers are investigated for use in advanced coatings, membranes, and engineering plastics.
Dendrimers and Nanostructures: Its symmetrical, polycyclic structure makes it a useful core for building complex dendritic molecules.

3. Organic Synthesis & Research

Model Compound: Used in physical organic chemistry studies to investigate steric effects and reaction mechanisms due to its unique, rigid geometry.
Ligand and Catalyst Design: Functionalized to create bulky ligands for metal catalysts or as a core for molecular recognition.

4. Analytical Chemistry

Sometimes used as a standard or reference compound in chromatography (like GC) and mass spectrometry due to its well-defined properties and stability.

Summary

Aspect	Description
What it is	A ketone-functionalized derivative of the stable adamantane cage.
Direct Uses	Very limited as an end-product.
Primary Value	A versatile chemical intermediate or building block.
Major Application	Synthesis of pharmaceuticals (e.g., Adapalene, Saxagliptin) and drug candidates.
Key Feature	Provides a rigid, stable, and lipophilic 3D scaffold that improves drug properties.

In essence, 2-Adamantanone is a workhorse molecule in the chemist's toolkit, prized for its ability to efficiently introduce the valuable adamantane structure into more complex, high-value molecules, especially in the pharmaceutical industry.