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Paracetamol/4-Acetamidophenol is mainly used for fever and headache caused by colds, alleviating other mild and moderate pain, such as joint pain, muscle pain, neuralgia, migraine, dysmenorrhea, cancer pain and postoperative analgesia.
Paracetamol/4-Acetamidophenol by inhibiting the synthesis of prostaglandins in the hypoamic thermoregulatory center, plays an antipyretic effect, its antipyretic intensity is similar to acetylsalicylic acid, by inhibiting the synthesis of prostaglandins in the central nervous system and blocking the impulse of pain nerve endings to produce analgesic effect, the effect is weaker than acetylsalicylic acid, compared with acetylsalicylic acid, it has the advantages of less irritation, rarely allergic reactions, and the antipyretic and analgesic effect is similar to phenacetin.
Items | Specifications | Results |
Appearance | White,odorless crystalline powder | |
Identification | A.Infrared Spectroscopy | Complies |
B.The retention time of the major peak of the Sample solution corresponds to that of the Standard solution,as obtained in the assay. | Complies | |
Solubility | Freely soluble in alcohol;soluble in boiling water and in 1N sodium Hydroxide | Comforms |
Loss on drying | Not more than 0.5% | 0.10% |
Residue on ignition | 0.05% | |
Free 4-aminophenol | Not more than 0.005% | 0.0001% |
Organic impurities | Relatedcompound B(N-(4-Hydroxyphenyl) Propanamide not more than 0.05% | 0.017% |
Relatedcompound C(N-(2- Hydroxyphenyl)acetamide)not more than 0.05% | ND(<LOD) | |
ND(<LOD) | ||
Related compound J(p-chloracetanilide)not more than 0.001% | ND(<LOD) | |
Any unspecified impurity not more than 0.05% | 0.014% | |
Total impurities not more than 0.1% | 0.048% | |
Residual solvent | Residual content of acetic acid is limited by the test of loss on drying not more than 0.5% | 0.10% |
Assay(on the dried basis) | 98.0%~102.0% | 100.0% |
Particle size | D50 D90 | 13.835μm 106.447μm |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 103-90-2 |
| Appearance: | White crystalline powder |
| Purity: | 98.0% - 102.0% |
| Package details: | 25kg/drum;25kg/bag |
| Brand: | Fortunachem |
Acetaminophen (also known as paracetamol outside the U.S. and Canada) is a common over-the-counter (OTC) medication used primarily to relieve pain and reduce fever. It is one of the most widely used pain relievers in the world.
Chemical Class: It is not an NSAID (non-steroidal anti-inflammatory drug like ibuprofen or aspirin). It works differently, mainly in the central nervous system (brain and spinal cord).
How it Works: While its exact mechanism isn't fully understood, it is believed to work by blocking the production of prostaglandins (chemicals that cause pain and fever) in the brain, while having minimal effect on inflammation in the rest of the body.
Forms: It is available in many forms: tablets, capsules, liquid, chewable tablets, dissolvable powders, and suppositories. It is also a very common ingredient in many combination cold, flu, and sinus medicines.
Pain Relief (Analgesic): Used to treat mild to moderate pain from various conditions, such as:
Headaches (including tension headaches)
Muscle aches and back pain
Arthritis pain (though it doesn't reduce joint inflammation)
Toothaches and pain after dental procedures
Menstrual cramps (period pain)
Minor aches and pains associated with the common cold or flu.
Fever Reduction (Antipyretic): Used to reduce fever. It is a standard go-to medicine for fevers in both adults and children.
You will often find acetaminophen sold under brand names such as:
Tylenol (the most well-known brand in the U.S.)
Panadol
FeverAll
Mapap
It is also the "APAP" or "acetam" component in many prescription pain relievers like Percocet (oxycodone/acetaminophen) or Tylenol with Codeine.
While safe and effective when used as directed, acetaminophen carries a major risk in cases of overdose, which can cause severe, sometimes fatal, liver damage.
Key Safety Rules:
Stick to the Recommended Dose: Do not exceed the maximum daily limit. For adults, this is generally 3,000 to 4,000 milligrams (mg) per day, but always follow the label instructions or your doctor's advice. Lower limits may apply for those with liver problems or who consume alcohol regularly.
Avoid "Double-Dipping": This is the most common cause of accidental overdose. Acetaminophen is in hundreds of combination medicines. Always check the active ingredients of all other medicines you are taking (for cold, flu, allergies, or prescription painkillers) to avoid taking multiple products containing acetaminophen.
Alcohol Warning: Consuming three or more alcoholic drinks per day while taking acetaminophen significantly increases the risk of liver damage.
Liver Disease: People with liver disease (like hepatitis or cirrhosis) must consult a doctor before use.
Overdose Symptoms: Early signs of overdose can be non-specific (nausea, vomiting, loss of appetite) but can progress to liver failure. Overdose is a medical emergency.
Acetaminophen is a widely accessible and effective medication for reducing fever and treating mild to moderate pain. Its main advantage is that it doesn't cause stomach upset or bleeding like NSAIDs can. However, its safety is entirely dependent on strict adherence to dosage guidelines to prevent the serious risk of liver toxicity.
Disclaimer: This information is for educational purposes only and is not medical advice. Always read and follow the label, and consult with a healthcare professional or pharmacist if you have any questions or underlying health conditions.




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