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7-Dehydrocholesterol is used as an important intermediate for vitamin D3. 7-Dehydrocholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 . 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.
Item | Specification | Result |
Appearance | White powder | White powder |
Assay | 99.0%min | 99.2% |
Product parameters | |
Cas number: | 434-16-2 |
Appearance: | white powder |
Purity: | 99.0% |
Package details: | 1kg/foil bag,25kg/drum |
Brand: | Fortunachem |
MF:C27H44O
MW:384.64
EINECS No.:207-100-5
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