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Aliskiren hemifumarate is a blood pressure-lowering drug and is safe and tolerable. Aliskiren hemifumarate has been used to treat hypertension, alone or with other antihypertensive medications. It is suitable for oral administration. Aliskiren hemifumarate regulates baseline systolic and diastolic blood pressure by blocking the catalytic activity of renin system at its rate-limiting step.
Aliskiren hemifumarate is a potent renin inhibitor. It has antihypertensive activity, decreasing plasma renin activity and inhibiting the conversion of angiotensinogen to Angiotensin I by binding to the S3 sub-pocket of renin. Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model.
Items | Specifications | Results |
Appearance | Off-White to Brown powder | Off-White powder |
Loss on drying | ≤0.5% | 0.28% |
Residue on Ignition | ≤0.5% | 0.16% |
Heavy Metals | ≤20PPM | 15PPM |
Assay | ≥98.0% | 99.25% |
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Product parameters | |
Cas number: | 173334-58-2 |
Appearance: | Off-White to Brown powder |
Purity: | 98%min |
Package details: | 25g/bottle; 1kg/foil bag |
Brand: | Fortunachem |
Used in the treatment of hypertension.
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