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AZD-9291(Mesylate) is used to treat patients with advanced non-small cell lung cancer with epidermal growth factor receptor (EGFR) T790M mutations or resistance to other EGFR inhibitors. AZD-9291 (Mesylate) is active against exon 19 deletions, exon 21 mutations, and also the exon 20 T790M mutations. It is preferentially selective for mutated EGFR, and therefore toxicity at therapeutic doses is lower than for first- and second-generation agents. Notably, AZD-9291 (Mesylate) is able to cross the blood-brain barrier, making it active against disease in the CNS.
| Items | Specification | Result |
Assay | ≥99.5% | 99.91% |
Appearance | Yellow powder | Complies |
| Water | ≤0.5% | N.D |
| Any single impurity | ≤0.1% | 0.04% |
| Total impurities | ≤0.5% | 0.09% |
| Residue Solvents | Ethyl acetate≤0.5% | 0.098% |
| Methanol≤0.3% | 0.169% |
| Product parameters | |
| Cas number: | 1421373-66-1 |
| Appearance: | Yellow powder |
| Purity: | 99.5%min |
| Package details: | 1kg/foil bag;25kg/drum |
| Brand: | Fortunachem |
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