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Benzydamine hydrochloride is a pharmaceutical salt with the chemical formula C₁₉H₂₃N₃O·HCl. Its structure features an indazole ring as the core, linked to a benzyl group and a 3-(dimethylamino)propoxy chain. The basic dimethylamino group is protonated, forming the water-soluble hydrochloride salt. This non-steroidal anti-inflammatory drug (NSAID) acts primarily as a local analgesic and anti-inflammatory agent, likely through membrane stabilization and prostaglandin inhibition. It is used topically in mouthwashes and sprays to treat inflammatory conditions of the mouth and throat.
| Items | Specifications | Results |
| Appearance | White crystalline powder | Conforms |
| Assay | ≥99% | 99.71% |
| Product parameters | |
| Cas number: | 132-69-4 |
| Appearance: | White crystalline powder |
| Purity: | 99%min |
| Package details: | 1kg/foil bag; 25kg/fiber drum |
| Brand: | Fortunachem |
Benzydamine hydrochloride is the hydrochloride salt of benzydamine, a medicinally active compound with analgesic, anti-inflammatory, and antipyretic properties. It is chemically classified as a non-steroidal anti-inflammatory drug (NSAID) with a unique structure.
Its chemical name is 1-benzyl-3-[3-(dimethylamino)propoxy]-1H-indazole hydrochloride.
Indazole Core: The central structure is an indazole ring system—a fused bicyclic aromatic ring containing a five-membered ring with two adjacent nitrogen atoms. This is a key pharmacophore.
Benzyl Group: A benzyl group (C₆H₅-CH₂-) is attached to the nitrogen (N-1) of the indazole ring. This lipophilic group contributes to membrane permeability and receptor binding.
Aminoalkoxy Chain: A three-carbon chain (propoxy linker) connects the indazole ring to a terminal tertiary dimethylamino group (-N(CH₃)₂). This basic nitrogen center is crucial for its pharmacological activity.
Hydrochloride Salt: The molecule exists as a hydrochloride salt, where the dimethylamino group is protonated, forming a positively charged ammonium ion ([-NH(CH₃)₂]⁺) paired with a chloride counterion (Cl⁻). This salt form enhances the compound's water solubility and stability for pharmaceutical formulation.
While its exact mechanism is not fully elucidated, it primarily functions as a local anti-inflammatory agent. Its action is strongly linked to the stabilization of cell membranes (lysosomal membranes) and the inhibition of prostaglandin synthesis, similar to other NSAIDs, though it may have a more localized, non-systemic effect.
Its main use is topical (not systemic) treatment of inflammatory conditions of the mouth and throat (e.g., pharyngitis, tonsillitis, and post-surgical pain in dentistry). It is commonly found as a mouthwash, spray, or lozenge. The structure's amphiphilic nature (containing both lipophilic and hydrophilic regions) aids in its local penetration and action on mucous membranes.
This product is a non-specific anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic effects.
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