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Celecoxib has the anti-inflammatory and analgesic effect of NSAIDs. Because of its chemical structure, it can be combined with COX-2, selectively inhibiting COX-2. Its phenyl group binds with the hydrophobic channel of COX-2, and its hydrophilic sulfonamide forms a hydrogen chain with 513 arginine and 90 histidine in the COX-2 "side pocket.” It is also in close contact with arginine in the COX-2120 position and plays a role in inhibiting COX-2 from converting arachidonic acid to prostaglandins which are harmful to the human body. Due to subtle differences between the structures of COX-1 and COX-2, Celecoxib cannot enter the COX-1 molecule, nor inhibit its transformation of arachidonic acid into prostaglandins. Thus, it has good anti-inflammatory and analgesic effects, protects gastric mucosa, protects renal blood flow, regulates platelet aggregation, and resolves the gastric irritation problems of commonly used NSAIDs.
Celecoxib is a new generation of nonsteroidal anti-inflammatory analgesics that inhibit prostaglandin production by selectively inhibiting cyclooxygenase-2 (COX-2) to achieve anti-inflammatory and analgesic effects.
| Items | Standard | results |
| Characters | The white or almost white crystalline powder | The almost white crystalline powder |
| Heavy metals | ≤0.002% | ＜0.002% |
| Loss on drying | ≤0.5% | 0.02% |
| Sulfated ash | ≤0.1% | 0.04% |
| Related substance | Single impurity≤0.5% | 0.21% |
| Total impurities≤1.0% | 0.23% | |
| Assay | ≥99.0% | 99.8% |
| Product parameters | |
| Cas number: | 169590-42-5 |
| Appearance: | Almost white crystalline powder |
| Purity: | 99.0% min |
| Package details: | 1kg/foil bag, 25kg/drum |
| Brand: | Fortunachem |
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