Name: China Factory Supply High Quality Best Price Ciprofibrate CAS 52214-84-3
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Ciprofibrate CAS 52214-84-3

Items	Specifications	Results
Appearance	White or slightly yellow, crystalline powder.	Off-white crystalline power
Solubility	Practically insoluble in water, freely soluble in anhydrous ethanol, soluble in toluene.	Conform
Infrared absorption	Conform	Conform
Chlorides	≤350 ppm	Conform
Melting point	About 115℃	117.5~117.6℃
Sulphated ash	≤0.1%	0.08%
Water	≤0.5%	0.11%
Solvent residues	Toluene ≤800 ppm n-Hexane ≤290 ppm	693.2ppm 86.6ppm
Appearance of solution.	The solution is clear and not more intensely coloured than reference solution BY4	Conform
Related substances	- impurity A ≤0.10%	N.D
	- impurity B ≤0.20%	N.D
	- impurity C ≤0.10%	N.D
	- impurity D ≤0.10%	N.D
	- impurity E ≤0.8%	N.D
	- any other impurity ≤0.10%	0.08%
	- total impurities ≤0.5%	0.19%
	-disregard impurity ≤0.05%	N.D
Assay (anhydrous substance)	99.0~101.0%	100.55%
Conclusion	The product Complies to EP9.0 standard.

Parameters of Ciprofibrate CAS 52214-84-3

Product parameters
Cas number:	52214-84-3
Appearance:	White or almost white crystalline powder
Purity:	99% min
Package details:	25kg/drum
Brand:	Fortunachem

Ciprofibrate is a medication belonging to the fibrate class of drugs (also known as fibric acid derivatives). It is used primarily to lower high levels of triglycerides and cholesterol in the blood.

It is known for being a very potent fibrate with a long duration of action, allowing for once-daily dosing.

1. Chemical Structure and Classification

Chemical Class: It is a fibric acid derivative, similar to other fibrates like fenofibrate and gemfibrozil, but with a distinct chemical structure that contributes to its high potency and long half-life.
Key Feature: Its structure includes a dichlorocyclopropyl group, which makes it highly lipid-soluble and contributes to its long-lasting effect in the body.

2. Mechanism of Action (How it Works)

Ciprofibrate works through several mechanisms, primarily by activating a specific nuclear receptor:

Primary Target: PPAR-alpha: Ciprofibrate is an agonist for the Peroxisome Proliferator-Activated Receptor alpha (PPAR-α). Activating this receptor changes the expression of genes involved in lipid metabolism.
Key Effects on Lipids:

Lowers Triglycerides (Major Effect): It dramatically increases the breakdown and clearance of triglycerides from the blood by stimulating the enzyme lipoprotein lipase (LPL). It also reduces the liver's production of Very-Low-Density Lipoprotein (VLDL), which is the main carrier of triglycerides.
Lowers LDL Cholesterol: It can moderately lower Low-Density Lipoprotein (LDL - "bad") cholesterol.
Raises HDL Cholesterol: It typically increases High-Density Lipoprotein (HDL - "good") cholesterol by increasing its synthesis.

3. Primary Uses (Therapeutic Indications)

Ciprofibrate is used to treat specific types of dyslipidemia (abnormal blood lipid levels), particularly in patients who have not responded adequately to diet, exercise, and other first-line medications like statins.

Its main uses include:

Hypertriglyceridemia: Treatment of very high triglyceride levels (Type IV and V hyperlipidemia) to prevent pancreatitis.
Mixed Dyslipidemia: Treatment of combined high triglycerides and low HDL cholesterol, often found in metabolic syndrome.
Hypercholesterolemia: It can be used to treat high cholesterol, though statins are usually preferred first-line.

4. Important Considerations and Side Effects

Potency and Dosing: It is one of the most potent fibrates available. Due to its long half-life (~80 hours), it is taken only once a day.
Common Side Effects:

Gastrointestinal issues (dyspepsia, nausea, diarrhea).
Skin rashes.
Muscle pain (myalgia) and weakness.

Serious Side Effects and Risks:

Muscle Toxicity (Myopathy/Rhabdomyolysis): The risk is significantly increased when ciprofibrate is taken together with a statin (e.g., atorvastatin, simvastatin). This combination requires extreme caution and close monitoring.
Liver Function Abnormalities: Can cause an increase in liver enzymes (transaminases).
Cholelithiasis: Increases the risk of developing gallstones because it increases the cholesterol content of bile.
Renal Impairment: Should be used with caution in patients with pre-existing kidney disease, as it can be excreted by the kidneys.

Contraindications:

Severe liver or kidney disease.
Pre-existing gallbladder disease.
Pregnancy and breastfeeding.

Comparison with Statins

Feature	Ciprofibrate (a Fibrate)	Statins (e.g., Atorvastatin)
Primary Effect	Lowers Triglycerides dramatically, raises HDL	Lowers LDL Cholesterol dramatically
Mechanism	Activates PPAR-alpha receptor	Inhibits HMG-CoA reductase enzyme
Best For	Hypertriglyceridemia, low HDL	Hypercholesterolemia, high LDL
Key Risk	Muscle toxicity, especially when combined with statins	Muscle toxicity (alone or in combination)

Summary

In essence, Ciprofibrate is a potent, long-acting fibrate drug used to correct abnormal blood lipid levels, with a particularly strong effect on reducing high triglycerides. Its use is highly effective but requires careful medical supervision due to the risk of serious side effects, especially muscle damage, particularly if used in combination with statin medications.