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Erlotinib hydrochloride is mainly used for second- or third-line treatment of locally advanced or metastatic non-small cell lung cancer and the treatment of pancreatic cancer.
Erlotinib hydrochloride is a receptor tyrosine kinase inhibitor that inhibits phosphorylation reaction by inhibiting the phosphorylation reaction by binding to the intracellular region catalytic site of receptor tyrosine kinase, which competently binds to adenosine triphosphate in cells, thereby blocking downward proliferative signaling, inhibiting the activity of HER-1/EGFR dependent on tumor cell ligands, and achieving the effect of inhibiting tumor cell proliferation.
| Items | Specification | Result |
| Appearance | White or almost white crystalline powder | Conform |
| Assay | 98%-102% | 99.5% |
| Loss on drying | ≤0.5% | 0.2% |
| Residue on ignition | ≤0.1% | 0.05% |
| Heavy metals | ≤20ppm | <20ppm |
| Related substance | Max single impurity≤0.2% Total impurity≤1.0% | 0.09% 0.20% |
| Product parameters | |
| Cas number: | 183319-69-9 |
| Appearance: | White or almost white crystalline powder |
| Purity: | 98%-102% |
| Package details: | 100g,1kg/foil bag |
| Brand: | Fortunachem |
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