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Etoricoxib is widely used in the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, chronic low back pain, acute gouty arthritis, primary dysmenorrhea and postoperative pain. Etoricoxib is a dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1 in several assays, e.g., in the production of PGE2 by CHO cells expressing either COX-2 (IC50 = 79 nM) or COX-1 (IC50 > 50 μM). Oral etoricoxib is well absorbed and metabolized extensively via oxidation, with metabolites excreted largely in the urine.
Items | Specification | Result |
Assay | ≥99% | 99.7% |
Appearance | White crystalline powder | Conform |
Loss on drying | ≤1.0% | 0.2% |
Heavy metals | ≤20ppm | Conform |
Product parameters | |
Cas number: | 202409-33-4 |
Appearance: | White crystalline powder |
Purity: | 99%min |
Package details: | 1kg/foil bag;25kg/drum |
Brand: | Fortunachem |
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