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Leflunomide has an immunosuppressive and anti-inflammatory effect and is used in the treatment of active rheumatoid arthritis in adults.
Leflunomide is rapidly converted into active metabolites by the cytoplasm and microsomes of the liver and intestinal wall, and its mechanism of action is mainly to inhibit the activity of a key enzyme in the DNA synthesis process - dihydroorotic acid dehydrogenase (DHODH), so that the nucleotides in B lymphocytes are depleted, the biosynthesis of DNA and RNA is terminated, so that the cells cannot enter the S phase, and eventually can not proliferate, thereby producing anti-rheumatic effects, suitable for the treatment of adult active rheumatoid arthritis, ankylosing spondylitis, May slow bone destruction and reduce signs and symptoms. In addition, leflunomide can also inhibit the activity of tyrosine kinase, thereby inhibiting the proliferation of T cells, B cells and non-immune cells, and can also exert anti-inflammatory effects by inhibiting the synthesis of prostaglandins by inhibiting the biosynthesis of cyclooxygenase-2 (COX2), and can inhibit the release of histamine in mast cells and basophils.
| Items | Specification |
| Product name | Leflunomide |
| CAS | 75706-12-6 |
| Appearance | White crystalline powder |
| Assay | ≥99% |
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 |
| EINECS | 616-254-6 |
| Product parameters | |
| Cas number: | 75706-12-6 |
| Appearance: | White crystalline powder |
| Purity: | 99%min |
| Package details: | 100g,1kg/foil bag |
| Brand: | Fortunachem |
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