Name: China Supplier High Quality Best Price Losartan Potassium CAS 124750-99-8
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Losartan Potassium CAS 124750-99-8

Items	Specification	Result
Appearance	White to off-white powder	Complies
Assay	98.5%-101%	99.8%
Water	≤0.5%	0.14%
Heavy metals	≤10ppm	<10ppm
Related substance	Any individual impurity≤0.2% Total impurity≤0.5%	0.02% 0.05%

Parameters of Losartan Potassium CAS 124750-99-8

Product parameters
Cas number:	124750-99-8
Appearance:	White to off-white powder
Purity:	98.5%-101%
Package details:	1kg/foil bag;25kg/drum
Brand:	Fortunachem

Losartan Potassium - Core Definition & Key Details

Losartan potassium is an angiotensin II receptor blocker (ARB), a class of antihypertensive drugs. It acts by selectively blocking the binding of angiotensin II (a vasoconstrictor hormone) to AT1 receptors in blood vessels, adrenal glands, and other tissues, thereby dilating blood vessels, reducing peripheral vascular resistance, and lowering blood pressure. It also has renal protective effects by reducing glomerular pressure.

Basic Chemical & Pharmaceutical Information

CAS Number: 124750-99-8
Molecular Formula: C22H22ClKN6O
Molecular Weight: 461.01 g/mol
Physical Properties: White to off-white crystalline powder, soluble in water, methanol, and ethanol; stable under normal storage conditions.

Primary Uses of Losartan Potassium

Hypertension (Essential Hypertension)

First-line treatment for mild to moderate hypertension in adults and pediatric patients (≥6 years old). It can be used alone or in combination with other antihypertensive drugs (e.g., diuretics like hydrochlorothiazide) to achieve target blood pressure control.
Advantage: Does not cause dry cough (a common side effect of ACE inhibitors), making it a preferred alternative for patients intolerant to ACE inhibitors.

Diabetic Nephropathy (Type 2 Diabetes)

Indicated for hypertensive patients with type 2 diabetes and diabetic nephropathy (evidenced by elevated urinary albumin/creatinine ratio). It reduces proteinuria and slows the progression of renal damage by lowering intraglomerular pressure and protecting renal microvasculature.

Heart Failure (Adjunctive Treatment)

Used as an adjunct to standard therapy (e.g., beta-blockers, diuretics, ACE inhibitors) in patients with chronic heart failure (NYHA class II-IV) to improve cardiac function, reduce hospitalization risk, and improve long-term prognosis (especially in patients intolerant to ACE inhibitors).

Reduction of Stroke Risk

For hypertensive patients with left ventricular hypertrophy (LVH), losartan potassium reduces the risk of stroke (primary endpoint in clinical trials like LIFE study) by controlling blood pressure and reversing LVH.

Important Notes

Contraindications: Hypersensitivity to losartan potassium or any component of the formulation; severe renal impairment (GFR <30 mL/min/1.73m²) without close monitoring; pregnancy (category D, risk of fetal harm).
Common Side Effects: Dizziness, fatigue, hypotension (especially in volume-depleted patients), hyperkalemia (monitor serum potassium regularly), and mild elevation of liver enzymes.
Dosage Adjustment: Renal/hepatic impairment may require dose reduction; individualize based on blood pressure response.