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The chemical structure of mosapride citrate is similar to cisapride , both of which are benzamide derivatives. The mechanism of gastric motility of the two drugs is also similar, both promote gastric emptying by stimulating the 5-HT4 receptors of the muscular plexus of the intestine, resulting in increased acetylcholine release of nerve endings. Unlike cisapride , mosapride citrate selectively acts on the upper gastrointestinal tract and has no effect on colonic motility, reducing side effects such as abdominal pain, increased frequency of bowel movements, diarrhea and soft stools due to colonic hypermotility, and because it has no affinity with dopamine D2 receptors, it can avoid side effects such as extrapyramidal reactions and increased prolactin secretion caused by antagonism of dopamine D2 receptors.
Mosapride citrate is used for the relief of chronic gastritis, functional dyspepsia, reflux esophagitis and a range of gastrointestinal symptoms associated with surgery.
| Item | Specifications | Results |
| Appearance | White to off white crystalline powder | Conform |
| Heavy Metal | ≤10ppm | Conform |
| Water | 5.0 – 6.0% | 5.6% |
| Residue on ignition | ≤0.1% | 0.02% |
| Assay | 98.0% - 101.5% | 99.5% |
| Product parameters | |
| Cas number: | 112885-42-4 |
| Appearance: | White to off white crystalline powder |
| Purity: | 98.0% - 101.5% |
| Package details: | 1kg/foil bag,25kg/drum |
| Brand: | Fortunachem |
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