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Naphazoline nitrate is used for colds, rhinitis, nasal congestion and so on.
Naphazoline nitrate is a topical vasoconstrictor medication, chemically formulated as a salt for stability. It is an alpha-adrenergic agonist that rapidly constricts dilated blood vessels.
Its primary medical uses are:
Ophthalmic: In eye drops, it relieves minor eye redness and irritation from allergies or minor conditions by whitening the sclera.
Nasal: As a nasal spray, it acts as a decongestant for temporary relief of nasal/sinus congestion from colds or allergies.
Critical Warning: It is strictly for short-term use (3-4 days maximum). Prolonged use can cause severe rebound congestion, worsening the original symptoms. Systemic absorption, especially in children, can lead to serious side effects like hypertension, sedation, and respiratory depression. It is contraindicated in individuals with certain heart, blood pressure, or eye conditions.
| Item | Specifications | Results |
| Appearance | White or almost white crystalline powder | Conform |
| PH | 5.0 – 65 | 6.1 |
| Loss on drying | ≤0.5% | 0.19% |
| Assay | 99.0% - 101.0% | 99.32% |
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| Product parameters | |
| Cas number: | 5144-52-5 |
| Appearance: | White or almost white crystalline powder |
| Purity: | 99.0% - 101.0% |
| Package details: | 1kg/foil bag |
| Brand: | Fortunachem |
Naphazoline nitrate is a salt form of naphazoline, which is a sympathomimetic amine belonging to the imidazoline derivative class. It functions primarily as a potent vasoconstrictor.
It is an alpha-adrenergic receptor agonist. When applied topically, it rapidly constricts blood vessels (vasoconstriction) in the area, reducing blood flow and swelling.
Its main uses are all related to its ability to shrink swollen mucous membranes and reduce redness:
Ophthalmic (Eye Drops):
Use: Temporary relief of eye redness (allergic conjunctivitis, minor irritation) by constricting conjunctival blood vessels.
Common Brands: Often combined with antihistamines (e.g., pheniramine) in products like Napheon-A®, Visine-A®.
Nasal (Nasal Spray/Drops):
Use: As a nasal decongestant to provide rapid, short-term relief from nasal/sinus congestion due to colds, allergies, or sinusitis.
Short-Term Use Only: Recommended for no more than 3-4 days. Prolonged use can cause rebound congestion (rhinitis medicamentosa), a condition where symptoms worsen after the medication wears off.
Systemic Effects: Overuse or accidental ingestion (especially in children) can lead to serious systemic side effects like hypertension, bradycardia, drowsiness, and central nervous system depression.
Contraindications: Not for use with certain medical conditions (e.g., narrow-angle glaucoma, severe hypertension, heart disease) or with MAO inhibitor antidepressants.
In summary, naphazoline nitrate is a fast-acting topical vasoconstrictor used for temporary relief of eye redness and nasal congestion, but its use must be strictly limited to a few days to avoid significant side effects and rebound phenomena.
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