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Nelarabine is used as a pharmaceutical intermediate.
Nelarabine is demethylated from methyl to ara-G under the action of adenosine deaminase (ADA) and then converted to active ara-G triphosphate (ara-GTP) by monophosphorylation pathway under the action of deoxyguanosine kinase and deoxycytidine kinase. ara-GTP can gradually accumulate in leukemia blasts and bind to DNA, thereby inhibiting DNA synthesis and promoting leukemia cell death.
Item | Specifications | Results |
Appearance | White or white crystalline powder | Conform |
Purity | ≥99.0% | 99.5% |
Loss on drying | ≤0.5% | 0.06% |
Chloride | ≤0.1% | Conform |
Residue on Ignition | ≤0.1% | 0.06% |
Product parameters | |
Cas number: | 121032-29-9 |
Appearance: | White or off white crystalline powder |
Purity: | 99.0% min |
Package details: | 100g/bag |
Brand: | Fortunachem |
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