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Ozanimod is mainly used in the treatment of multiple sclerosis, ulcerative colitis and Crohn's disease.
Ozanimod is a sphingosine-1-phosphate receptor 1 (S1P1) and S1P5 agonist. It induces GTPγS binding in cell membranes expressing human S1P1 or S1P5 (EC50s = 0.41 and 11 nM, respectively) but not cell membranes expressing S1P2 or S1P3 receptors (EC50s = >10,000 nM for both). Ozanimod (0.2 mg/kg) reduces the number of peripheral lymphocytes in rats. It reduces disease severity and the number of circulating lymphocytes in a mouse model of experimental autoimmune encephalomyelitis (EAE). Ozanimod (0.3 and 1 mg/kg) reduces disease severity and body weight loss in a mouse model of TNBS-induced colitis. Formulations containing ozanimod have been used in the treatment of relapsing multiple sclerosis and ulcerative colitis.
Items | Specifications | Results |
Appearance | White powder | Conforms |
Assay | ≥95% | 95.83% |
Product parameters | |
Cas number: | 1306760-87-1 |
Appearance: | White powder |
Purity: | 95%min |
Package details: | 50g/bottle; 1kg/foil bag |
Brand: | Fortunachem |
Used as an autoimmune disease agent.
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