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Potassium oxonate is one component of the anticancer drug S-1, which inhibits the toxic side effects of the antitumor drug tegafur.
Potassium oxonate is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.
| Items | Specification | Result |
| Assay | ≥98.5% | 99.52% |
| Apperance | White to off-white crystalline powder | White crystalline powder |
| Related substances | ≤1.0% | 0.48% |
| Loss on drying | ≤1.0% | 0.16% |
| Heavy metal | ≤20ppm | Complies |
| Product parameters | |
| Cas number: | 2207-75-2 |
| Appearance: | White to off-white crystalline powder |
| Purity: | 98.5%min |
| Package details: | 1kg/foil bag;25kg/drum |
| Brand: | Fortunachem |
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