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Simvastatin has the effect of lowering cholesterol, low density lipoprotein. Simvastatin catalyzes the conversion of β-methyl-β-hydroxyglutaric acid coenzyme A (HMG-CoA) to β methyl-p-α dihydroxyvalerate, and is a specific inhibitor of HMG-CoA reductase. Simvastatin is used in primary hypercholesterolemia, heterozygous familial and nonfamilial hypercholesterolemia, or mixed hyperlipidemia that do not respond well to dietary therapy, and has a significant effect on reducing total cholesterol and LDL cholesterol.
| Items | Specification | Result |
| Assay | 97%-102% | 98.7% |
| Appearance | White or almost white crystalline powder | Almost white crystalline powder |
| Specific optical rotation | +285°~+300° | +291.2° |
| Related substance | Impurity A≤0.4% Impurity D≤0.4% Impurity G≤0.1% Any unspecified impurity≤0.1% Total impurities≤1.0% | 0.06% 0.09% 0.05% 0.09% 0.53% |
| Loss on drying | ≤0.5% | 0.03% |
| Heavy metals | ≤20ppm | <20ppm |
| Sulphated ash | ≤0.1% | 0.03% |
| Product parameters | |
| Cas number: | 79902-63-9 |
| Appearance: | White or almost white crystalline powder |
| Purity: | 97%-102% |
| Package details: | 1kg/foil bag;25kg/drum |
| Brand: | Fortunachem |
Simvastatin (brand name Zocor) is a widely prescribed medication belonging to the class of drugs known as statins (HMG-CoA reductase inhibitors). It is primarily used to lower cholesterol levels and reduce the risk of cardiovascular disease.
Here are its key functions and selling points:
1. Primary Functions (What it does)
Lowers "Bad" Cholesterol (LDL): It inhibits the enzyme HMG-CoA reductase in the liver, which is responsible for producing cholesterol. This significantly reduces Low-Density Lipoprotein (LDL) levels (by 26–47%).
Raises "Good" Cholesterol (HDL): It helps increase High-Density Lipoprotein (HDL) levels (by 8–16%), which helps remove cholesterol from the arteries.
Reduces Triglycerides: It lowers triglyceride levels in the blood (by 12–33%).
Plaque Stabilization: Beyond lowering lipids, it helps stabilize existing plaque in artery walls, reducing the risk of rupture that leads to heart attacks or strokes.
2. Core Selling Points (Why it is chosen)
Proven Cardiovascular Protection: Backed by landmark studies (like the 4S Study), Simvastatin is proven not just to lower numbers, but to reduce mortality, prevent heart attacks, and reduce the need for coronary revascularization procedures (like bypass surgery or angioplasty).
Cost-Effectiveness: As a generic medication available for decades, it is extremely affordable compared to newer statins, making it a first-line choice for health systems and patients worldwide.
Potent Efficacy: At moderate to high doses (20–40 mg), it offers a strong balance of potency and safety, suitable for patients with moderate to high cardiovascular risk.
Pleiotropic Effects: Emerging research suggests it has anti-inflammatory and endothelial-improving properties independent of cholesterol lowering, providing extra vascular protection.
Established Safety Profile: With millions of patient-years of use, its side effect profile is well-understood and managed, giving clinicians confidence in prescribing it.
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