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Sorafenib tosylate is used in the treatment of advanced liver cancer. Sorafenib tosylate simultaneously inhibits a variety of kinases present in and on the cell surface, including RAF kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet-derived growth factor receptor-β (PDGFR-β), KIT, and FLT-3. It can be seen that sorafenib tosylate has a dual anti-tumor effect, on the one hand, it can directly inhibit tumor growth by inhibiting the RAF/MEK/ERK signaling pathway; On the other hand, it can block the formation of tumor neovascularization by inhibiting VEGFR and PDGFR, and indirectly inhibit the growth of tumor cells.
Items | Specification |
Product name | Sorafenib tosylate |
CAS | 475207-59-1 |
Appearance | White powder |
Assay | ≥99% |
Molecular Formula | C28H24ClF3N4O6S |
Molecular Weight | 637.0265696 |
EINECS | 641-758-8 |
Product parameters | |
Cas number: | 475207-59-1 |
Appearance: | White powder |
Purity: | 99%min |
Package details: | 1kg/foil bag |
Brand: | Fortunachem |
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