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Topiramate is a broad-spectrum antiepileptic drug that can be used to control different types of epilepsy; its efficacy and pharmacokinetics are good.
TPM can exert its efficacy in treating epilepsy through various kinds of mechanisms including:
1, blocking the voltage-dependent sodium channels and thereby reducing the duration of epileptic discharges and the number of action potentials generated during each discharge. 2, antagonizing kainate/AMPA--glutamate receptors. 3, enhancing the GABA activity in the non-benzodiazepine position of the GABA receptor. 4, mildly inhibiting carbonic anhydrase. 5, blocking the T-type calcium channels. 6, block the activity of the excitatory neurotransmitter of the central nervous AMPA glutamate receptor.
Product Name | Topiramate |
Apperance | White powder |
EINECS | 200-659-6 |
MF | C12H21NO8S |
MW | 339.36 |
Assay | ≥99.0% |
Product parameters | |
Cas number: | 97240-79-4 |
Appearance: | White powder |
Purity: | 99% min |
Package details: | 25kg/drum |
Brand: | Fortunachem |
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