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Tranexamic Acid is a synthetic derivative of lysine, which is a commonly used hemostatic drug in clinical practice, which exerts hemostasis by inhibiting the dissolution of fibrin. Tranexamic acid can inhibit plasmin, plasminogen and fibrin binding, thereby strongly inhibiting the breakdown of fibrin caused by plasmin, in addition, in the presence of anti-plasmin such as macroglobulin in the serum, the antifibrinolytic effect of tranexamic acid is more obvious.
The chemical structure of tranexamic acid is similar to lysine, which can competitively inhibit the adsorption of plasminogen on fibrin, prevent its activation, protect fibrin from being degraded and dissolved by plasmin, and finally achieve hemostatic effect. It is suitable for the treatment of various bleeding caused by acute or chronic, localized or systemic primary fibrinolysis, such as obstetric hemorrhage, renal hemorrhage, prostatic hypertrophy hemorrhage, hemophilia, tuberculosis hemorrhage, gastric bleeding, bleeding after liver, lung, spleen and other visceral surgery; It can also be used for abnormal bleeding during surgery.
| Items | Specifications | Results |
| Appearance | White crystalline powder | White crystalline Powder |
| PH | 7.0～8.0 | 7.2 |
| Heavy metals | ≤10ppm | ＜10ppm |
| Loss on drying | ≤0.5% | 0.22% |
| Sulphated ash | ≤0.1% | 0.05% |
| Assay | 99.0%～101.0% | 99.8% |
| Product parameters | |
| Cas number: | 1197-18-8 |
| Appearance: | White crystalline powder |
| Purity: | 99%min |
| Package details: | 1kg/foil bag; 25kg/drum |
| Brand: | Fortunachem |
Tranexamic Acid is a synthetic (man-made) medication that prevents the breakdown of blood clots. It's an antifibrinolytic agent, meaning it helps stabilize clots and stop bleeding.
To understand how it works, it's helpful to know a little about your body's natural processes:
Clot Formation (Hemostasis): When you bleed, your body forms a clot to stop the bleeding. This clot is made of a protein called fibrin.
Clot Breakdown (Fibrinolysis): Once the injury is healed, your body naturally produces an enzyme called plasmin to break down the fibrin clot. This is a crucial cleanup process.
Tranexamic acid works by inhibiting plasminogen activators (which turn into plasmin). Essentially, it puts a temporary "brake" on the system that dissolves clots. By slowing down fibrinolysis, it gives the body's initial clots more time to become stable and effectively stop the bleeding.
Tranexamic acid has several important medical applications:
1. Heavy Menstrual Bleeding (Menorrhagia):
This is one of its most common uses. It significantly reduces blood loss during periods, improving quality of life for many women.
2. Surgical Procedures:
It is frequently used before, during, and after surgery (especially cardiac surgery, orthopedic surgery like joint replacements, and major trauma surgery) to reduce blood loss and the need for blood transfusions.
3. Trauma and Major Bleeding:
It is a critical drug in emergency medicine for people with severe bleeding from traumatic injuries (e.g., car accidents). Given early, it can reduce the risk of death from bleeding.
4. Hereditary Angioedema:
It is used as a preventative treatment to reduce the frequency of attacks of this genetic disorder, which causes rapid swelling in various parts of the body.
5. Topical Use in Skincare:
In recent years, tranexamic acid has gained popularity as a topical treatment (in serums, creams, etc.) for:
Hyperpigmentation: Particularly melasma and post-inflammatory hyperpigmentation (dark spots left after acne or skin injuries).
How it works for skin: It's believed to interfere with the interaction between melanocytes (skin pigment cells) and keratinocytes (skin surface cells), preventing the transfer of pigment. It also inhibits the plasminogen pathway in the skin, which is activated by UV light and triggers melanin production.
Tranexamic acid is available in several forms:
Oral Tablets: For heavy menstrual bleeding and preventative care.
Intravenous (IV) Injection: For major bleeding, during surgery, or in emergency settings.
Topical: As a cream, lotion, or serum for skincare.
Mouthwash: Sometimes used for dental bleeding in patients with bleeding disorders.
While highly effective, it's not without risks.
Key Contraindication (When NOT to use it):
History of Blood Clots: It should not be used by people with a history of, or at high risk for, thrombosis (blood clots), such as deep vein thrombosis (DVT), pulmonary embolism (PE), or stroke. Because the drug prevents clot breakdown, it can increase this risk.
Common Side Effects:
Oral/IV: Nausea, vomiting, diarrhea, stomach pain.
IV: A temporary drop in blood pressure if injected too quickly.
Topical: Generally well-tolerated, but can cause mild skin irritation, redness, or itching.
Serious Side Effects (Seek medical help immediately):
Symptoms of a blood clot: sudden shortness of breath, chest pain, leg pain or swelling, sudden vision changes, weakness on one side of the body, or slurred speech.
Severe allergic reactions are rare but possible.
Tranexamic acid is a prescription medication (for oral and IV forms). You should always use it under the guidance of a doctor who can assess your personal risk factors, especially for blood clots. Even the topical form is best used after consultation with a dermatologist.
In summary, Tranexamic Acid is a versatile and potent medication that promotes clotting by preventing the body's natural clot-dissolving process. Its uses range from saving lives in trauma to managing heavy periods and improving skin discoloration.
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