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The mode of action of dihydroartemisinin mainly interferes with the epimembrane-mitochondrial function of the malaria parasite. Through its internal peroxide (dioxygen) bridge, mediated by free iron produced by hemoglobin breakdown, the production of unstable organic radicals and/or other electrophilic intermediaries is then covalent adducts with the proteins of the malaria parasite, causing the malaria parasite to die. Ingestion of tritium-labeled isoleucine by Plasmodium falciparum cultured in vitro has also suggested that its initiation of action may be inhibition of protozoal protein synthesis.
Dihydroartemisinin is an artemisinin derivative that has a powerful and rapid killing effect on the red internal stage of malaria parasite, and can quickly control clinical onset and symptoms. It has the same effect against chloroquine and anti-piperaquine falciparum malaria.
| Item | Specifications | Results |
| Appearance | Colorless needle crystal | Conform |
| Heavy Metal | ≤10ppm | ＜5ppm |
| Loss on drying | ≤0.5% | 0.35% |
| Residue on ignition | ≤0.1% | 0.04% |
| Assay(on a dry basis) | 98% - 102% | 98.4% |
| Product parameters | |
| Cas number: | 71939-50-9 |
| Appearance: | Colorless needle crystal |
| Purity: | 98% - 102% |
| Package details: | 1kg/foil bag;25kg/drum |
| Brand: | Fortunachem |
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