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Menatetrenone/Vitamin K2 has a osteogenesis effect, which can promote calcium metabolism and inhibit bone resorption caused by osteoclasts, thereby increasing bone density and preventing osteoporosis.
Menatetrenone is a naturally occurring vitamin that contains the basic structure of menaquinone and has anti-bleeding effects. Menatetrenone can promote the synthesis of prothrombin in the liver and regulate the synthesis of coagulation factors VII., IX., and X., thereby accelerating blood clotting. In addition, it plays an important role in glucose phosphorylation within cells.
Items | Specification | Result |
| Assay | 98%-102% | 99.73% |
| Apperance | Yellow crystalline powder | Yellow crystalline powder |
| Related substances | Single impurity≤1.0% Total impurities≤2.0% | 0.17% 0.54% |
| Isomer | ≤2.0% | 0.18% |
| Melting point | 36.5~37.5℃ | 35.64℃ |
| Product parameters | |
| Cas number: | 863-61-6 |
| Appearance: | Yellow crystalline powder |
| Purity: | 98%-102% |
| Package details: | 10g,100g,1kg/foil bag |
| Brand: | Fortunachem |
Product Name: Menatetrenone (Vitamin K2 / MK-4)
CAS No.: 863-61-6
Molecular Formula: C31H40O2
Appearance: Yellow crystalline powder or viscous oil (lipid-soluble)
Purity: ≥98% / ≥99% (HPLC)
Key Functions & Applications
Menatetrenone is a specific form of Vitamin K2 (Menaquinone-4). Unlike Vitamin K1 (phylloquinone) which is primarily involved in blood clotting, Menatetrenone has a distinct biological role in bone metabolism and cardiovascular health. It acts as a crucial cofactor for the carboxylation of glutamate residues in specific proteins.
1. Bone Health & Osteoporosis Management
Menatetrenone is essential for the activation of osteocalcin, a protein responsible for binding calcium to the bone matrix. By promoting the carboxylation of osteocalcin, it helps increase bone mineral density and is widely used as a therapeutic agent for osteoporosis.
2. Cardiovascular Support
It activates Matrix Gla Protein (MGP), a potent inhibitor of vascular calcification. By preventing calcium deposition in arterial walls, Menatetrenone supports arterial flexibility and overall heart health.
3. Pharmaceutical & Clinical Use
It is an approved active pharmaceutical ingredient (API) used in formulations for treating vitamin K deficiency, hemorrhagic diseases, and as an adjunct therapy for osteoporosis pain.
4. High-End Nutraceuticals
Due to its superior bioavailability compared to synthetic analogs, it is a premium ingredient in bone health supplements and anti-aging formulations.
Key Selling Points (Why Choose Our Menatetrenone?)
High Purity & Potency: Manufactured to ≥98% or ≥99% purity (HPLC), ensuring maximum biological activity for your formulations.
Bioactive Form: This is the natural MK-4 form, the most biologically active version of Vitamin K2, offering superior efficacy in bone metabolism compared to other variants.
Strict Quality Control: Low residual solvents, heavy metals within safe limits, and consistent batch-to-batch stability.
Versatile Application: Suitable for softgel capsules, lipid-based injections, and oil-based dietary supplements.
Scientific Backing: Extensively researched and documented for its role in gamma-carboxylation, apoptosis induction, and cell cycle regulation.
Reliable Supply: Stable production capacity with proper light-protected packaging (essential for light-sensitive Vitamin K) to ensure delivery of high-quality material.
Typical Specifications
Parameter Specification
Appearance Yellow powder or oil
Assay (HPLC) ≥98.0% / ≥99.0%
Loss on Drying ≤0.5%
Residue on Ignition ≤0.5%
Heavy Metals ≤10 ppm
Solubility Soluble in ethanol, lipids; Insoluble in water
Guaranteed purity
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