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Oxytetracycline mainly interferes with and inhibits the synthesis of proteins, thereby producing the effect of killing microorganisms, and has inhibitory effects on gram-positive bacteria, gram-negative bacteria, mycoplasma, chlamydia, rickettsia, spirochetes, porcine erythrocyte bodies, etc.
Oxytetracycline has an inhibitory effect on both gram-positive and gram-negative bacteria and is also used as a growth promoter.
Items | Specifications | Results |
Appearance | Pale yellow crystalline powder | Complies |
Identification | A. UV Absorption at 353nm is between 96.0% and 104.0% B. Colour reaction with sulfuric acid | 97.5% Complies |
Crystallinity | Meets the requirements | Complies |
pH | 4.5 to 7.0 | 5.3 |
Water | 6.0% to 9.0% | 7.6% |
Assay | Not less than 832ug/mg | 872ug/mg |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 79-57-2 |
| Appearance: | Yellow crystalline powder |
| Purity: | 95.0% - 102.0% |
| Package details: | 20kg/drum |
| Brand: | Fortunachem |
Uses:
Oxytetracycline (OTC) — trade name Terramycin — is a natural tetracycline-class broad-spectrum antibiotic, originally isolated from the actinomycete Streptomyces rimosus and launched by Pfizer in 1950. It remains one of the highest-volume antibiotic APIs in the world, used overwhelmingly in animals rather than people.
| Item | Details |
|---|---|
| CAS | 79-57-2 (base); 2058-46-0 (HCl salt); 6153-64-6 (dihydrate) |
| Formula / MW | C₂₂H₂₄N₂O₉ / 460.44 g/mol (HCl salt 496.90) |
| Appearance | Yellow crystalline powder, bitter |
| Solubility | Very slightly soluble in water; freely soluble in dilute acid/alkali; soluble in HCl salt form |
| Stability | Stable in air; light-sensitive (darkens); stable in acid, destroyed in alkaline solution; chelates Ca/Mg/Fe/Al |
| Mechanism | Reversibly binds bacterial 30S ribosomal subunit (A site), blocks aminoacyl-tRNA → inhibits protein synthesis; bacteriostatic (bactericidal at high concentration) |
| Spectrum | Gram-positive (staph, strep, clostridia, anthrax), Gram-negative (E. coli, Salmonella, Pasteurella, Haemophilus, Brucella), plus Mycoplasma, Chlamydia, Rickettsia, Actinomyces, Leptospira, some protozoa (Entamoeba) |
| ATCvet | QJ01AA06 |
Resistance is now widespread via tet(A)/tet(B) efflux pumps, tet(M) ribosomal protection, and enzymatic inactivation, with full cross-resistance across the tetracycline class. This single fact shapes where OTC can still be sold and used.
Uses
1. Veterinary medicine (the dominant market, ~80%+ of volume)
Cattle: bovine respiratory disease/shipping fever, foot rot, infectious bovine keratoconjunctivitis ("pink eye"), leptospirosis
Swine: enzootic pneumonia (Mycoplasma hyopneumoniae), pasteurellosis, colibacillosis/salmonella enteritis, atrophic rhinitis, leptospirosis abortion control
Poultry: chronic respiratory disease, infectious synovitis, cholera
Small animals: ophthalmic ointment (Terramycin OTC + Polymyxin B), skin/soft-tissue infections, feline chlamydiosis
Bees: American/European foulbrood (where still permitted)
Forms: injectable LA solutions (200 mg/mL), boluses, premixes/medicated feed, water-soluble powders, tablets, eye ointment
2. Aquaculture — Terramycin 200 for Fish (VFD drug, US): furunculosis, columnaris, coldwater disease, ulcer disease in salmonids; hemorrhagic septicemia in catfish; also used in shrimp/shellfish in Asia. Also used as a bone-marking agent in salmonid research.
3. Human medicine (now narrow and second-line) — rickettsial diseases (typhus, Rocky Mountain spotted fever, Q fever), chlamydial infections/trachoma, mycoplasma, brucellosis/tularemia/plague (with aminoglycoside), cholera, acne vulgaris and ocular rosacea (low-dose, long course), penicillin-allergic alternatives (syphilis, leptospirosis, actinomycosis), topical ophthalmic/skin ointments. Largely displaced by doxycycline/minocycline due to PK and resistance.
4. Agriculture/plant protection — spray for fire blight (Erwinia amylovora) in apples/pears as a streptomycin alternative (~100–200 mg/L), and certain bacterial plant diseases (regulated; residues tightly controlled).
5. Research/industrial — selective antibiotic in microbiology media (e.g., OGYE for yeast/mould counts), resistance-gene studies (otrA), cell biology (phagosome–lysosome fusion, mitochondrial protein synthesis inhibition), environmental fate/ARG studies, reference standard for residue analysis (LC-MS/MS, ELISA kits).
Selling points
Broadest practical spectrum in its class — covers Gram± plus Mycoplasma/Chlamydia/Rickettsia in one molecule; ideal for undifferentiated or mixed infections and mass medication.
Lowest cost per treated animal-day — mature Streptomyces fermentation, huge Chinese/Indian capacity, commodity pricing (bulk HCl salt typically low double-digit USD/kg); far cheaper than macrolides, fluoroquinolones or 3rd/4th-gen cephalosporins.
Multiple routes and formulations — injection, feed, water, bolus, topical/ophthalmic; the same API serves herds, flocks, ponds and pets, simplifying procurement.
Long-acting injectable depot forms — LA 200 mg/mL gives sustained levels with fewer handling events, reducing labour stress in extensive cattle/sheep operations.
Established regulatory footprint — defined MRLs, withdrawal periods (meat ~22–37 d, milk ~168 h depending on product/country), Codex/VFD pathways, pharmacopoeia monographs (USP/EP/BP/ChP) → easier registration than novel actives.
Proven safety/history of use — 75 years of field data, known antidote/supportive profile, no genotoxicity red flags at therapeutic doses; familiar to vets and farmers.
Dual human–animal–agro platform — one molecule spans pharma, vet, aqua and crop, enabling portfolio breadth and by-product/salt synergy (base/HCl/dihydrate/calcium).
Technical robustness — stable crystalline powder, long shelf life if protected from light/moisture; easy to blend into premixes; simple potency assays.
Adjunct value — anti-inflammatory/lipase-inhibiting effect in acne and rosacea at sub-antimicrobial doses; useful where that dual action is marketed.
Limitations you must disclose (these are the real deal-breakers)
Resistance: high and rising in E. coli, Pasteurella, Vibrio, Mycoplasma; efficacy must be justified by sensitivity testing; cross-resistant with all tetracyclines.
Regulatory squeeze: EU bans on routine/metaphylactic use and national feed-antibiotic prohibitions; US VFD-only medicated feed; China's 2020 feed-additive antibiotic ban; aquaculture withdrawal 15–21+ days and residue monitoring. Not a growth promoter.
Human contraindications: children <8 years, pregnancy/lactation, hepatic or renal impairment; photosensitivity; GI upset; superinfection; chelation with dairy/antacids/iron reduces absorption.
Animal cautions: lactating dairy cows (milk discard), horses, young animals (teeth/bone), overdose hepatotoxicity; do not mix with penicillins/cephalosporins, bicarbonate, lime, or metal ions.
Environmental: persistent, binds sediments, drives ARG spread in mariculture soils — a reputational and compliance risk increasingly scrutinised by buyers and certifiers (ASC/BAP).
Quality specs matter: assay/potency (µg/mg), 4-epi-oxytetracycline, apo-oxytetracycline, loss on drying, heavy metals, sterility/endotoxin for injectables — buyers will demand CoA + GMP/DMF/COP.
Commercial positioning in one line
"A proven, low-cost, broad-spectrum tetracycline workhorse for herd, flock and pond health — widest formulation choice and the deepest regulatory file in its class, best deployed where sensitivity is confirmed and withdrawal/residue discipline can be guaranteed."
Target customers: generic vet-pharma formulators, feed-mill premix makers, aquaculture integrators, beekeeping suppliers, agrochemical distributors (fire blight), and labs needing reference standards. Differentiate on potency consistency + epimer/impurity control + documented residue-depletion data, not on spectrum alone.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Oxytetracycline with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Oxytetracycline.
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